Reaction Details Report a problem with these data
Target
A disintegrin and metalloproteinase with thrombospondin motifs 5 [262-930,L692P]
Ligand
BDBM28327
Substrate
WAAG-3R
Meas. Tech.
ADAMTS-5 Enzyme Inhibition Assay
pH
7.5±n/a
Temperature
310.15±n/a K
IC50
78±n/a nM
Citation
 Shiozaki, M; Maeda, K; Miura, T; Ogoshi, Y; Haas, J; Fryer, AM; Laird, ER; Littmann, NM; Andrews, SW; Josey, JA; Mimura, T; Shinozaki, Y; Yoshiuchi, H; Inaba, T Novel N-substituted 2-phenyl-1-sulfonylamino-cyclopropane carboxylates as selective ADAMTS-5 (Aggrecanase-2) inhibitors. Bioorg Med Chem Lett 19:1575-80 (2009) [PubMed]  Article 
Target
Name:
A disintegrin and metalloproteinase with thrombospondin motifs 5 [262-930,L692P]
Synonyms:
A disintegrin and metalloproteinase with thrombospondin motifs 5 | ADAM-TS 11 | ADAMTS-5 (Aggrecanase-2) | ADAMTS11 | ADAMTS5 | ADMP-2 | ADMP2 | ATS5_HUMAN
Type:
Metalloprotease
Mol. Mass.:
73728.14
Organism:
Homo sapiens (Human)
Description:
Q9UNA0[262-930,L692P]
Residue:
669
Sequence:
SISRARQVELLLVADASMARLYGRGLQHYLLTLASIANRLYSHASIENHIRLAVVKVVVLGDKDKSLEVSKNAATTLKNFCKWQHQHNQLGDDHEEHYDAAILFTREDLCGHHSCDTLGMADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSHDDSKFCEETFGSTEDKRLMSSILTSIDASKPWSKCTSATITEFLDDGHGNCLLDLPRKQILGPEELPGQTYDATQQCNLTFGPEYSVCPGMDVCARLWCAVVRQGQMVCLTKKLPAVEGTPCGKGRICLQGKCVDKTKKKYYSTSSHGNWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPRNNGRYCTGKRAIYRSCSLMPCPPNGKSFRHEQCEAKNGYQSDAKGVKTFVEWVPKYAGVLPADVCKLTCRAKGTGYYVVFSPKVTDGTECRPYSNSVCVRGKCVRTGCDGIIGSKLQYDKCGVCGGDNSSCTKIVGTFNKKSKGYTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKKKNGEYLINGKYMISTSETIIDINGTVMNYSGWSHRDDFLHGMGYSATKEILIVQILATDPTKPLDVRYSFFVPKKSTPKVNSVTSHGSNKVGSHTSQPQWVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKGCPLSQRPSAFKQCLLKKC
  
Inhibitor
Name:
BDBM28327
Synonyms:
(1R,2S)-1-{[4-(4-chlorophenyl)benzene][2-(3-methoxy-2-oxo-1,2-dihydropyridin-1-yl)ethyl]sulfonamido}-2-phenylcyclopropane-1-carboxylic acid | sulfonylamino-alkanecarboxylate, 41
Type:
Small organic molecule
Emp. Form.:
C30H27ClN2O6S
Mol. Mass.:
579.063
SMILES:
COc1cccn(CCN([C@@]2(C[C@H]2c2ccccc2)C(O)=O)S(=O)(=O)c2ccc(cc2)-c2ccc(Cl)cc2)c1=O |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
WAAG-3R
Synonyms:
n/a
Type:
Fluorescent peptide
Mol. Mass.:
1954.08
Organism:
n/a
Description:
n/a
Residue:
19
Sequence:
ATEGEARGSVIDAPDNPKK