Target
5-hydroxytryptamine receptor 6
Ligand
BDBM28636
Substrate
BDBM21342
Meas. Tech.
Filtration Binding Assay
Temperature
298.15±n/a K
Ki
2.7±n/a nM
Comments
extracted
Citation
 Singer, JMWilson, MWJohnson, PDGraham, SRCooke, LWRoof, RLBoxer, PAGold, LHMeltzer, LTJanssen, ARoush, NCampbell, JESu, TZHurst, SIStoner, CLSchwarz, JB Synthesis and SAR of tolylamine 5-HT6 antagonists. Bioorg Med Chem Lett 19:2409-12 (2009) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 6
Synonyms:
5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46968.43
Organism:
Homo sapiens (Human)
Description:
P50406
Residue:
440
Sequence:
MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN
  
Inhibitor
Name:
BDBM28636
Synonyms:
2-methyl-3-(piperidin-4-yl)phenyl naphthalene-2-sulfonate | tolylpiperidine, 18n
Type:
Small organic molecule
Emp. Form.:
C22H23NO3S
Mol. Mass.:
381.488
SMILES:
Cc1c(OS(=O)(=O)c2ccc3ccccc3c2)cccc1C1CCNCC1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM21342
Synonyms:
(4R,7R)-N,N-diethyl-6-methyl-6,11-diazatetracyclo[7.6.1.0^{2,7}.0^{12,16}]hexadeca-1(16),2,9,12,14-pentaene-4-carboxamide | CHEMBL263881 | LSD | LSD 25 | LSD,(+) | LSD,l- | Lysergic Acid Diethylamide | Lysergic Acid Diethylamide Tartrate | [3H]-LSD | d-Isolysergic acid amide
Type:
radiolabeled ligand
Emp. Form.:
C20H25N3O
Mol. Mass.:
323.432
SMILES:
[H][C@@]12Cc3c[nH]c4cccc(C1=C[C@H](CN2C)C(=O)N(CC)CC)c34 |c:12|
Structure:
Search PDB for entries with ligand similarity: