Target
D-amino-acid oxidase
Ligand
BDBM31173
Substrate
BDBM23167
Meas. Tech.
DAAO in Vitro Activity Assay
pH
8.5±n/a
Temperature
295.15±n/a K
IC50
3±n/a nM
Citation
 Duplantier, AJBecker, SLBohanon, MJBorzilleri, KAChrunyk, BADowns, JTHu, LYEl-Kattan, AJames, LCLiu, SLu, JMaklad, NMansour, MNMente, SPiotrowski, MASakya, SMSheehan, SSteyn, SJStrick, CAWilliams, VAZhang, L Discovery, SAR, and pharmacokinetics of a novel 3-hydroxyquinolin-2(1H)-one series of potent D-amino acid oxidase (DAAO) inhibitors. J Med Chem 52:3576-85 (2009) [PubMed]  Article 
Target
Name:
D-amino-acid oxidase
Synonyms:
D-amino-acid oxidase (DAAO) | DAAO | DAMOX | DAO | OXDA_HUMAN
Type:
Homodimer
Mol. Mass.:
39476.06
Organism:
Homo sapiens (Human)
Description:
P14920
Residue:
347
Sequence:
MRVVVIGAGVIGLSTALCIHERYHSVLQPLDIKVYADRFTPLTTTDVAAGLWQPYLSDPNNPQEADWSQQTFDYLLSHVHSPNAENLGLFLISGYNLFHEAIPDPSWKDTVLGFRKLTPRELDMFPDYGYGWFHTSLILEGKNYLQWLTERLTERGVKFFQRKVESFEEVAREGADVIVNCTGVWAGALQRDPLLQPGRGQIMKVDAPWMKHFILTHDPERGIYNSPYIIPGTQTVTLGGIFQLGNWSELNNIQDHNTIWEGCCRLEPTLKNARIIGERTGFRPVRPQIRLEREQLRTGPSNTEVIHNYGHGGYGLTIHWGCALEAAKLFGRILEEKKLSRMPPSHL
  
Inhibitor
Name:
BDBM31173
Synonyms:
naphthyridinone analog., 27
Type:
Small organic molecule
Emp. Form.:
C8H4ClFN2O2
Mol. Mass.:
214.581
SMILES:
Oc1cc2c(Cl)c(F)cnc2[nH]c1=O
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM23167
Synonyms:
(2R)-2-amino-3-hydroxypropanoic acid | CHEMBL285123 | D-Serine
Type:
Amino Acid
Emp. Form.:
C3H7NO3
Mol. Mass.:
105.0926
SMILES:
N[C@H](CO)C(O)=O
Structure:
Search PDB for entries with ligand similarity: