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Target
Isoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL)
Ligand
BDBM32292
Substrate
F-Bim
Meas. Tech.
Multiplexed dose response screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-XL.
pH
7.4±n/a
Temperature
277.15±n/a K
EC50
28340±n/a nM
Citation
 PubChem, PC Multiplexed dose response screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-XL. PubChem Bioassay (2008)[AID] 
Target
Name:
Isoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL)
Synonyms:
B-cell lymphoma-extra large protein (Bcl-xL) | B2CL1_HUMAN | BCL-xL | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-xL) | Isoform Bcl-X(L)
Type:
Homodimers/heterodimers with BAX, BAK and BCL2
Mol. Mass.:
26053.63
Organism:
Homo sapiens (Human)
Description:
gi_510901
Residue:
233
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATAHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
  
Inhibitor
Name:
BDBM32292
Synonyms:
5-Bromo-nicotinic acid [1-[5-(2-nitro-phenyl)-furan-2-yl]-meth-(E)-ylidene]-hydrazide | 5-bromanyl-N-[[5-(2-nitrophenyl)furan-2-yl]methylideneamino]pyridine-3-carboxamide | 5-bromo-N-[[5-(2-nitrophenyl)-2-furanyl]methylideneamino]-3-pyridinecarboxamide | 5-bromo-N-[[5-(2-nitrophenyl)-2-furyl]methyleneamino]nicotinamide | 5-bromo-N-[[5-(2-nitrophenyl)furan-2-yl]methylideneamino]pyridine-3-carboxamide | MLS000591926 | SMR000218578 | cid_1914494
Type:
Small organic molecule
Emp. Form.:
C17H11BrN4O4
Mol. Mass.:
415.198
SMILES:
[O-][N+](=O)c1ccccc1-c1ccc([CH+][N-]NC(=O)c2cncc(Br)c2)o1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
F-Bim
Synonyms:
n/a
Type:
fluorescent peptide probe
Mol. Mass.:
3923.40
Organism:
n/a
Description:
n/a
Residue:
32
Sequence:
FITCAHDMRPEIWIAQELRRIGDEFNAYYARH