Target
Alpha-2C adrenergic receptor
Ligand
BDBM398511
Substrate
n/a
Meas. Tech.
Antagonism Against Adrenoreceptors
IC50
20.0±n/a nM
Citation
 Becker-Pelster, EMBuchgraber, PBuchmüller, AEngel, KGeiss, VGöller, AHimmel, HKast, RKnorr, ALang, DRedlich, GSchmeck, CTinel, HWunder, F Substituted piperidinyl tetrahydroquinolines US Patent  US10323020 Publication Date 6/18/2019 
Target
Name:
Alpha-2C adrenergic receptor
Synonyms:
ADA2C_HUMAN | ADRA2C | ADRA2L2 | ADRA2RL2 | Adrenergic alpha2C | Adrenergic receptor | Adrenergic receptor alpha | Adrenergic, alpha-2C-, receptor | Alpha-2 adrenergic receptor subtype C4 | Alpha-2C adrenoceptor | Alpha-2C adrenoreceptor | adrenergic, alpha-2C-, receptor [Homo sapiens]
Type:
Enzyme
Mol. Mass.:
49552.32
Organism:
Homo sapiens (Human)
Description:
P18825
Residue:
462
Sequence:
MASPALAAALAVAAAAGPNASGAGERGSGGVANASGASWGPPRGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSLYRQPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLSEKRAPVGPDGASPTTENGLGAAAGAGENGHCAPPPADVEPDESSAAAERRRRRGALRRGGRRRAGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRLSRASSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ
  
Inhibitor
Name:
BDBM398511
Synonyms:
(rac)-{2-[(1-Methoxybutan-2-yl)amino]pyrimidin-5-yl}[4-(6-methoxy-3,4-dihydroisoquinolin-2(1H)-yl)piperidin-1-yl]methanone | US10323020, Example 5
Type:
Small organic molecule
Emp. Form.:
C25H35N5O3
Mol. Mass.:
453.5771
SMILES:
CCC(COC)Nc1ncc(cn1)C(=O)N1CCC(CC1)N1CCc2cc(OC)ccc2C1
Structure:
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