Target
Dimer of Gag-Pol polyprotein [501-599,A572V]
Ligand
BDBM579
Substrate
Chromogenic peptide substrate
Meas. Tech.
Protease Inhibition Assay
pH
4.7±n/a
Temperature
310.15±n/a K
Ki
0.37±0.05 nM
Km
11000±1000 nM
kcat
4.7±0.2 1/sec
Citation
 Clemente, JCHemrajani, RBlum, LEGoodenow, MMDunn, BM Secondary mutations M36I and A71V in the human immunodeficiency virus type 1 protease can provide an advantage for the emergence of the primary mutation D30N. Biochemistry 42:15029-35 (2003) [PubMed]  Article 
Target
Name:
Dimer of Gag-Pol polyprotein [501-599,A572V]
Synonyms:
HIV-1 Protease Mutant (A71V)
Type:
Protein Complex
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Gag-Pol polyprotein [501-599,A572V]
Synonyms:
HIV-1 Protease Mutant (A71V) chain A | HIV-1 Protease Mutant (A71V) chain B | LAI (A71V) | POL_HV1BR | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
10823.24
Organism:
Human immunodeficiency virus type 1
Description:
P03367[501-599,A572V]
Residue:
99
Sequence:
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYDQILIEICGHKVIGTVLVGPTPVNIIGRNLLTQIGCTLNF
  
Component 2
Name:
Gag-Pol polyprotein [501-599,A572V]
Synonyms:
HIV-1 Protease Mutant (A71V) chain A | HIV-1 Protease Mutant (A71V) chain B | LAI (A71V) | POL_HV1BR | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
10823.24
Organism:
Human immunodeficiency virus type 1
Description:
P03367[501-599,A572V]
Residue:
99
Sequence:
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYDQILIEICGHKVIGTVLVGPTPVNIIGRNLLTQIGCTLNF
  
Inhibitor
Name:
BDBM579
Synonyms:
(4R)-N-tert-butyl-3-[(2S,3S)-2-hydroxy-3-[(2R)-2-[2-(isoquinolin-5-yloxy)acetamido]-3-(methylsulfanyl)propanamido]-4-phenylbutanoyl]-1,3-thiazolidine-4-carboxamide | CHEMBL414640 | KNI-272 | Kynostatin 272 | iQoa-Mta-Apns-Thz-NH-tBu
Type:
Small organic molecule
Emp. Form.:
C33H41N5O6S2
Mol. Mass.:
667.839
SMILES:
CSC[C@H](NC(=O)COc1cccc2cnccc12)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)C(=O)N1CSC[C@H]1C(=O)NC(C)(C)C |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Chromogenic peptide substrate
Synonyms:
Chromogenic peptide substrate
Type:
Peptide
Mol. Mass.:
1420.11
Organism:
n/a
Description:
n/a
Residue:
13
Sequence:
KARVLNPHEANLG