Reaction Details Report a problem with these data
Target
Bcl-2-related protein A1
Ligand
BDBM32292
Substrate
FITC-conjugated-Bim BH3 Peptide
Meas. Tech.
Multiplexed dose response screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bfl-1.
pH
7.4±n/a
Temperature
277.15±n/a K
EC50
33550±n/a nM
Citation
 PubChem, PC Multiplexed dose response screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bfl-1. PubChem Bioassay (2008)[AID] 
Target
Name:
Bcl-2-related protein A1
Synonyms:
B2LA1_HUMAN | BCL2A1 | BCL2L5 | BFL1 | Bcl-2-like protein 5 | GRS | HBPA1 | Hemopoietic-specific early response protein | Protein BFL-1 | Protein GRS
Type:
Apoptosis regulator protein
Mol. Mass.:
20130.01
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
175
Sequence:
MTDCEFGYIYRLAQDYLQCVLQIPQPGSGPSKTSRVLQNVAFSVQKEVEKNLKSCLDNVNVVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAFEGILIKKLLRQQIAPDVDTYKEISYFVAEFIMNNTGEWIRQNGGWENGFVKKFEPKSGWMTFLEVTGKICEMLSLLKQYC
  
Inhibitor
Name:
BDBM32292
Synonyms:
5-Bromo-nicotinic acid [1-[5-(2-nitro-phenyl)-furan-2-yl]-meth-(E)-ylidene]-hydrazide | 5-bromanyl-N-[[5-(2-nitrophenyl)furan-2-yl]methylideneamino]pyridine-3-carboxamide | 5-bromo-N-[[5-(2-nitrophenyl)-2-furanyl]methylideneamino]-3-pyridinecarboxamide | 5-bromo-N-[[5-(2-nitrophenyl)-2-furyl]methyleneamino]nicotinamide | 5-bromo-N-[[5-(2-nitrophenyl)furan-2-yl]methylideneamino]pyridine-3-carboxamide | MLS000591926 | SMR000218578 | cid_1914494
Type:
Small organic molecule
Emp. Form.:
C17H11BrN4O4
Mol. Mass.:
415.198
SMILES:
[O-][N+](=O)c1ccccc1-c1ccc([CH+][N-]NC(=O)c2cncc(Br)c2)o1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
FITC-conjugated-Bim BH3 Peptide
Synonyms:
FITC-Ahx-DMRPEIWIAQELRRIGDEFNAYYAR-OH
Type:
FITC-labeled Peptide
Mol. Mass.:
3112.46
Organism:
n/a
Description:
n/a
Residue:
25
Sequence:
DMRPEIWIAQELRRIGDEFNAYYAR