Reaction Details Report a problem with these data
Target
Bcl-2-related protein A1
Ligand
BDBM33110
Substrate
FITC-conjugated-Bim BH3 Peptide
Meas. Tech.
Multiplexed dose response screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bfl-1.
pH
7.4±n/a
Temperature
277.15±n/a K
EC50
4460±n/a nM
Citation
 PubChem, PC Multiplexed dose response screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bfl-1. PubChem Bioassay (2008)[AID] 
Target
Name:
Bcl-2-related protein A1
Synonyms:
B2LA1_HUMAN | BCL2A1 | BCL2L5 | BFL1 | Bcl-2-like protein 5 | GRS | HBPA1 | Hemopoietic-specific early response protein | Protein BFL-1 | Protein GRS
Type:
Apoptosis regulator protein
Mol. Mass.:
20130.01
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
175
Sequence:
MTDCEFGYIYRLAQDYLQCVLQIPQPGSGPSKTSRVLQNVAFSVQKEVEKNLKSCLDNVNVVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAFEGILIKKLLRQQIAPDVDTYKEISYFVAEFIMNNTGEWIRQNGGWENGFVKKFEPKSGWMTFLEVTGKICEMLSLLKQYC
  
Inhibitor
Name:
BDBM33110
Synonyms:
5-[(6-Bromo-2-hydroxy-naphthalen-1-ylmethylene)-amino]-1,3-dihydro-benzoimidazol-2-one | 5-[[(E)-(6-bromo-2-keto-1-naphthylidene)methyl]amino]-1,3-dihydrobenzimidazol-2-one | 5-[[(Z)-(6-bromanyl-2-oxidanylidene-naphthalen-1-ylidene)methyl]amino]-1,3-dihydrobenzimidazol-2-one | 5-[[(Z)-(6-bromo-2-keto-1-naphthylidene)methyl]amino]-1,3-dihydrobenzimidazol-2-one | 5-[[(Z)-(6-bromo-2-oxo-1-naphthalenylidene)methyl]amino]-1,3-dihydrobenzimidazol-2-one | 5-[[(Z)-(6-bromo-2-oxonaphthalen-1-ylidene)methyl]amino]-1,3-dihydrobenzimidazol-2-one | MLS000553451 | SMR000171789 | cid_5761516
Type:
Small organic molecule
Emp. Form.:
C18H12BrN3O2
Mol. Mass.:
382.211
SMILES:
Oc1ccc2cc(Br)ccc2c1C=Nc1ccc2[nH]c(=O)[nH]c2c1 |w:13.15|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
FITC-conjugated-Bim BH3 Peptide
Synonyms:
FITC-Ahx-DMRPEIWIAQELRRIGDEFNAYYAR-OH
Type:
FITC-labeled Peptide
Mol. Mass.:
3112.46
Organism:
n/a
Description:
n/a
Residue:
25
Sequence:
DMRPEIWIAQELRRIGDEFNAYYAR