Reaction Details Report a problem with these data
Target
Bcl-2-related protein A1
Ligand
BDBM33112
Substrate
FITC-conjugated-Bim BH3 Peptide
Meas. Tech.
Multiplexed dose response screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bfl-1.
pH
7.4±n/a
Temperature
277.15±n/a K
EC50
18270±n/a nM
Citation
 PubChem, PC Multiplexed dose response screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bfl-1. PubChem Bioassay (2008)[AID] 
Target
Name:
Bcl-2-related protein A1
Synonyms:
B2LA1_HUMAN | BCL2A1 | BCL2L5 | BFL1 | Bcl-2-like protein 5 | GRS | HBPA1 | Hemopoietic-specific early response protein | Protein BFL-1 | Protein GRS
Type:
Apoptosis regulator protein
Mol. Mass.:
20130.01
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
175
Sequence:
MTDCEFGYIYRLAQDYLQCVLQIPQPGSGPSKTSRVLQNVAFSVQKEVEKNLKSCLDNVNVVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAFEGILIKKLLRQQIAPDVDTYKEISYFVAEFIMNNTGEWIRQNGGWENGFVKKFEPKSGWMTFLEVTGKICEMLSLLKQYC
  
Inhibitor
Name:
BDBM33112
Synonyms:
3-(3-methylphenyl)-6-oxidanylidene-4-sulfanyl-2-thiophen-2-yl-1,2-dihydropyrimidine-5-carbonitrile | 3-(3-methylphenyl)-6-oxo-4-sulfanyl-2-thiophen-2-yl-1,2-dihydropyrimidine-5-carbonitrile | 4-mercapto-3-(3-methylphenyl)-6-oxo-2-thiophen-2-yl-1,2-dihydropyrimidine-5-carbonitrile | 6-Mercapto-4-oxo-2-thiophen-2-yl-1-m-tolyl-1,2,3,4-tetrahydro-pyrimidine-5-carbonitrile | 6-keto-4-mercapto-3-(m-tolyl)-2-(2-thienyl)-1,2-dihydropyrimidine-5-carbonitrile | MLS000559283 | SMR000178690 | cid_3158797
Type:
Small organic molecule
Emp. Form.:
C16H13N3OS2
Mol. Mass.:
327.424
SMILES:
Cc1cccc(c1)N1C(NC(=O)C(C#N)C1=S)c1cccs1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
FITC-conjugated-Bim BH3 Peptide
Synonyms:
FITC-Ahx-DMRPEIWIAQELRRIGDEFNAYYAR-OH
Type:
FITC-labeled Peptide
Mol. Mass.:
3112.46
Organism:
n/a
Description:
n/a
Residue:
25
Sequence:
DMRPEIWIAQELRRIGDEFNAYYAR