Target
Bcl-2-related protein A1
Ligand
BDBM33119
Substrate
FITC-conjugated-Bim BH3 Peptide
Meas. Tech.
Multiplexed dose response screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bfl-1.
pH
7.4±n/a
Temperature
277.15±n/a K
EC50
26810±n/a nM
Citation
 PubChem, PC Multiplexed dose response screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bfl-1. PubChem Bioassay (2008)[AID] 
Target
Name:
Bcl-2-related protein A1
Synonyms:
B2LA1_HUMAN | BCL2A1 | BCL2L5 | BFL1 | Bcl-2-like protein 5 | GRS | HBPA1 | Hemopoietic-specific early response protein | Protein BFL-1 | Protein GRS
Type:
Apoptosis regulator protein
Mol. Mass.:
20130.01
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
175
Sequence:
MTDCEFGYIYRLAQDYLQCVLQIPQPGSGPSKTSRVLQNVAFSVQKEVEKNLKSCLDNVNVVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAFEGILIKKLLRQQIAPDVDTYKEISYFVAEFIMNNTGEWIRQNGGWENGFVKKFEPKSGWMTFLEVTGKICEMLSLLKQYC
  
Inhibitor
Name:
BDBM33119
Synonyms:
2-({7-[(1-methyl-1H-imidazol-2-yl)thio]-4-nitro-2,1,3-benzoxadiazol-5-yl}amino)ethyl propionate | 2-[[7-(1-methylimidazol-2-yl)sulfanyl-4-nitro-2,1,3-benzoxadiazol-5-yl]amino]ethyl propanoate | MLS000584447 | SMR000207033 | cid_12005273 | propanoic acid 2-[[7-[(1-methyl-2-imidazolyl)thio]-4-nitro-2,1,3-benzoxadiazol-5-yl]amino]ethyl ester | propionic acid 2-[[7-[(1-methylimidazol-2-yl)thio]-4-nitro-benzofurazan-5-yl]amino]ethyl ester
Type:
Small organic molecule
Emp. Form.:
C15H16N6O5S
Mol. Mass.:
392.39
SMILES:
CCC(=O)OCCNc1cc(Sc2nccn2C)c2nonc2c1[N+]([O-])=O
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
FITC-conjugated-Bim BH3 Peptide
Synonyms:
FITC-Ahx-DMRPEIWIAQELRRIGDEFNAYYAR-OH
Type:
FITC-labeled Peptide
Mol. Mass.:
3112.46
Organism:
n/a
Description:
n/a
Residue:
25
Sequence:
DMRPEIWIAQELRRIGDEFNAYYAR