Reaction Details Report a problem with these data
Target
Bcl-2-related protein A1
Ligand
BDBM33129
Substrate
FITC-conjugated-Bim BH3 Peptide
Meas. Tech.
Multiplexed dose response screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bfl-1.
pH
7.4±n/a
Temperature
277.15±n/a K
EC50
41100±n/a nM
Citation
 PubChem, PC Multiplexed dose response screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bfl-1. PubChem Bioassay (2008)[AID] 
Target
Name:
Bcl-2-related protein A1
Synonyms:
B2LA1_HUMAN | BCL2A1 | BCL2L5 | BFL1 | Bcl-2-like protein 5 | GRS | HBPA1 | Hemopoietic-specific early response protein | Protein BFL-1 | Protein GRS
Type:
Apoptosis regulator protein
Mol. Mass.:
20130.01
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
175
Sequence:
MTDCEFGYIYRLAQDYLQCVLQIPQPGSGPSKTSRVLQNVAFSVQKEVEKNLKSCLDNVNVVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAFEGILIKKLLRQQIAPDVDTYKEISYFVAEFIMNNTGEWIRQNGGWENGFVKKFEPKSGWMTFLEVTGKICEMLSLLKQYC
  
Inhibitor
Name:
BDBM33129
Synonyms:
2-(9-ketoacridin-10-yl)-N-[(3-nitro-4-pyrrolidino-benzylidene)amino]acetamide | MLS000585799 | N'-[(1E)-(3-nitro-4-pyrrolidin-1-ylphenyl)methylene]-2-(9-oxoacridin-10(9H)-yl)acetohydrazide | N-[(3-nitro-4-pyrrolidin-1-yl-phenyl)methylideneamino]-2-(9-oxidanylideneacridin-10-yl)ethanamide | N-[(3-nitro-4-pyrrolidin-1-ylphenyl)methylideneamino]-2-(9-oxoacridin-10-yl)acetamide | N-[[3-nitro-4-(1-pyrrolidinyl)phenyl]methylideneamino]-2-(9-oxo-10-acridinyl)acetamide | SMR000204362 | cid_4027877
Type:
Small organic molecule
Emp. Form.:
C26H23N5O4
Mol. Mass.:
469.4919
SMILES:
[O-][N+](=O)c1cc(\C=N\NC(=O)Cn2c3ccccc3c(=O)c3ccccc23)ccc1N1CCCC1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
FITC-conjugated-Bim BH3 Peptide
Synonyms:
FITC-Ahx-DMRPEIWIAQELRRIGDEFNAYYAR-OH
Type:
FITC-labeled Peptide
Mol. Mass.:
3112.46
Organism:
n/a
Description:
n/a
Residue:
25
Sequence:
DMRPEIWIAQELRRIGDEFNAYYAR