Target
Bcl-2-related protein A1
Ligand
BDBM33140
Substrate
FITC-conjugated-Bim BH3 Peptide
Meas. Tech.
Multiplexed dose response screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bfl-1.
pH
7.4±n/a
Temperature
277.15±n/a K
EC50
15020±n/a nM
Citation
 PubChem, PC Multiplexed dose response screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bfl-1. PubChem Bioassay (2008)[AID] 
Target
Name:
Bcl-2-related protein A1
Synonyms:
B2LA1_HUMAN | BCL2A1 | BCL2L5 | BFL1 | Bcl-2-like protein 5 | GRS | HBPA1 | Hemopoietic-specific early response protein | Protein BFL-1 | Protein GRS
Type:
Apoptosis regulator protein
Mol. Mass.:
20130.01
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
175
Sequence:
MTDCEFGYIYRLAQDYLQCVLQIPQPGSGPSKTSRVLQNVAFSVQKEVEKNLKSCLDNVNVVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAFEGILIKKLLRQQIAPDVDTYKEISYFVAEFIMNNTGEWIRQNGGWENGFVKKFEPKSGWMTFLEVTGKICEMLSLLKQYC
  
Inhibitor
Name:
BDBM33140
Synonyms:
4-bromanyl-2-[(E)-3-(4-methoxyphenyl)prop-2-enoyl]-7-(methylamino)cyclohepta-2,4,6-trien-1-one | 4-bromo-2-[(E)-3-(4-methoxyphenyl)-1-oxoprop-2-enyl]-7-(methylamino)-1-cyclohepta-2,4,6-trienone | 4-bromo-2-[(E)-3-(4-methoxyphenyl)acryloyl]-7-(methylamino)cyclohepta-2,4,6-trien-1-one | 4-bromo-2-[(E)-3-(4-methoxyphenyl)prop-2-enoyl]-7-(methylamino)cyclohepta-2,4,6-trien-1-one | 4-bromo-2-[3-(4-methoxyphenyl)acryloyl]-7-(methylamino)-2,4,6-cycloheptatrien-1-one | MLS000702101 | SMR000229850 | cid_7314636
Type:
Small organic molecule
Emp. Form.:
C18H16BrNO3
Mol. Mass.:
374.229
SMILES:
CNc1ccc(Br)cc(C(=O)\C=C\c2ccc(OC)cc2)c1=O
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
FITC-conjugated-Bim BH3 Peptide
Synonyms:
FITC-Ahx-DMRPEIWIAQELRRIGDEFNAYYAR-OH
Type:
FITC-labeled Peptide
Mol. Mass.:
3112.46
Organism:
n/a
Description:
n/a
Residue:
25
Sequence:
DMRPEIWIAQELRRIGDEFNAYYAR