Reaction Details Report a problem with these data
Target
Bcl-2-related protein A1
Ligand
BDBM33170
Substrate
FITC-conjugated-Bim BH3 Peptide
Meas. Tech.
Multiplexed dose response screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bfl-1.
pH
7.4±n/a
Temperature
277.15±n/a K
EC50
5460±n/a nM
Citation
 PubChem, PC Multiplexed dose response screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bfl-1. PubChem Bioassay (2008)[AID] 
Target
Name:
Bcl-2-related protein A1
Synonyms:
B2LA1_HUMAN | BCL2A1 | BCL2L5 | BFL1 | Bcl-2-like protein 5 | GRS | HBPA1 | Hemopoietic-specific early response protein | Protein BFL-1 | Protein GRS
Type:
Apoptosis regulator protein
Mol. Mass.:
20130.01
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
175
Sequence:
MTDCEFGYIYRLAQDYLQCVLQIPQPGSGPSKTSRVLQNVAFSVQKEVEKNLKSCLDNVNVVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAFEGILIKKLLRQQIAPDVDTYKEISYFVAEFIMNNTGEWIRQNGGWENGFVKKFEPKSGWMTFLEVTGKICEMLSLLKQYC
  
Inhibitor
Name:
BDBM33170
Synonyms:
4-(2-chloranyl-5-ethenylsulfonyl-4-nitro-thiophen-3-yl)morpholine | 4-(2-chloro-4-nitro-5-vinylsulfonyl-3-thienyl)morpholine | 4-(2-chloro-5-ethenylsulfonyl-4-nitro-3-thiophenyl)morpholine | 4-(2-chloro-5-ethenylsulfonyl-4-nitrothiophen-3-yl)morpholine | MLS000708371 | SMR000287838 | cid_3155287
Type:
Small organic molecule
Emp. Form.:
C10H11ClN2O5S2
Mol. Mass.:
338.788
SMILES:
[O-][N+](=O)c1c(sc(Cl)c1N1CCOCC1)S(=O)(=O)C=C
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
FITC-conjugated-Bim BH3 Peptide
Synonyms:
FITC-Ahx-DMRPEIWIAQELRRIGDEFNAYYAR-OH
Type:
FITC-labeled Peptide
Mol. Mass.:
3112.46
Organism:
n/a
Description:
n/a
Residue:
25
Sequence:
DMRPEIWIAQELRRIGDEFNAYYAR