Reaction Details Report a problem with these data
Target
Bcl-2-related protein A1
Ligand
BDBM33177
Substrate
FITC-conjugated-Bim BH3 Peptide
Meas. Tech.
Multiplexed dose response screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bfl-1.
pH
7.4±n/a
Temperature
277.15±n/a K
EC50
34450±n/a nM
Citation
 PubChem, PC Multiplexed dose response screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bfl-1. PubChem Bioassay (2008)[AID] 
Target
Name:
Bcl-2-related protein A1
Synonyms:
B2LA1_HUMAN | BCL2A1 | BCL2L5 | BFL1 | Bcl-2-like protein 5 | GRS | HBPA1 | Hemopoietic-specific early response protein | Protein BFL-1 | Protein GRS
Type:
Apoptosis regulator protein
Mol. Mass.:
20130.01
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
175
Sequence:
MTDCEFGYIYRLAQDYLQCVLQIPQPGSGPSKTSRVLQNVAFSVQKEVEKNLKSCLDNVNVVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAFEGILIKKLLRQQIAPDVDTYKEISYFVAEFIMNNTGEWIRQNGGWENGFVKKFEPKSGWMTFLEVTGKICEMLSLLKQYC
  
Inhibitor
Name:
BDBM33177
Synonyms:
1-(2-furanylmethyl)-2-[(2-methoxyphenyl)-oxomethyl]imino-5-oxo-3-dipyrido[1,2-d:3',4'-f]pyrimidinecarboxylic acid ethyl ester | 1-(2-furfuryl)-5-keto-2-o-anisoylimino-dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxylic acid ethyl ester | MLS000729830 | SMR000308107 | cid_2152512 | ethyl (2Z)-1-(2-furylmethyl)-2-[(2-methoxybenzoyl)imino]-5-oxo-1,5-dihydro-2H-dipyrido[1,2-a:2',3'-d]pyrimidine-3-carboxylate | ethyl 1-(furan-2-ylmethyl)-2-(2-methoxybenzoyl)imino-5-oxodipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxylate | ethyl 1-(furan-2-ylmethyl)-2-(2-methoxyphenyl)carbonylimino-5-oxidanylidene-dipyrido[1,2-d:3',4'-f]pyrimidine-3-carboxylate
Type:
Small organic molecule
Emp. Form.:
C27H22N4O6
Mol. Mass.:
498.4868
SMILES:
CCOC(=O)c1cc2c(nc3ccccn3c2=O)n(Cc2ccco2)\c1=N\C(=O)c1ccccc1OC
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
FITC-conjugated-Bim BH3 Peptide
Synonyms:
FITC-Ahx-DMRPEIWIAQELRRIGDEFNAYYAR-OH
Type:
FITC-labeled Peptide
Mol. Mass.:
3112.46
Organism:
n/a
Description:
n/a
Residue:
25
Sequence:
DMRPEIWIAQELRRIGDEFNAYYAR