Reaction Details Report a problem with these data
Target
Bcl-2-related protein A1
Ligand
BDBM33178
Substrate
FITC-conjugated-Bim BH3 Peptide
Meas. Tech.
Multiplexed dose response screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bfl-1.
pH
7.4±n/a
Temperature
277.15±n/a K
EC50
9180±n/a nM
Citation
 PubChem, PC Multiplexed dose response screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bfl-1. PubChem Bioassay (2008)[AID] 
Target
Name:
Bcl-2-related protein A1
Synonyms:
B2LA1_HUMAN | BCL2A1 | BCL2L5 | BFL1 | Bcl-2-like protein 5 | GRS | HBPA1 | Hemopoietic-specific early response protein | Protein BFL-1 | Protein GRS
Type:
Apoptosis regulator protein
Mol. Mass.:
20130.01
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
175
Sequence:
MTDCEFGYIYRLAQDYLQCVLQIPQPGSGPSKTSRVLQNVAFSVQKEVEKNLKSCLDNVNVVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAFEGILIKKLLRQQIAPDVDTYKEISYFVAEFIMNNTGEWIRQNGGWENGFVKKFEPKSGWMTFLEVTGKICEMLSLLKQYC
  
Inhibitor
Name:
BDBM33178
Synonyms:
(4-bromophenyl)-(4-chlorodithiazol-5-ylidene)amine | MLS000728902 | N-(4-bromophenyl)-4-chloranyl-1,2,3-dithiazol-5-imine | N-(4-bromophenyl)-4-chloro-5-dithiazolimine | N-(4-bromophenyl)-4-chlorodithiazol-5-imine | N-(4-bromophenyl)-N-[(5Z)-4-chloro-5H-1,2,3-dithiazol-5-ylidene]amine | SMR000307180 | cid_715703
Type:
Small organic molecule
Emp. Form.:
C8H4BrClN2S2
Mol. Mass.:
307.618
SMILES:
Clc1nss\c1=N/c1ccc(Br)cc1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
FITC-conjugated-Bim BH3 Peptide
Synonyms:
FITC-Ahx-DMRPEIWIAQELRRIGDEFNAYYAR-OH
Type:
FITC-labeled Peptide
Mol. Mass.:
3112.46
Organism:
n/a
Description:
n/a
Residue:
25
Sequence:
DMRPEIWIAQELRRIGDEFNAYYAR