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Target
Genome polyprotein [1424-1463]/[1502-1685]
Ligand
BDBM33265
Substrate
BDBM33263
Meas. Tech.
Protease Inhibition Assay
pH
8.5±n/a
Temperature
296.15±n/a K
Ki
13000±1000 nM
Citation
 Ganesh, VK; Muller, N; Judge, K; Luan, CH; Padmanabhan, R; Murthy, KH Identification and characterization of nonsubstrate based inhibitors of the essential dengue and West Nile virus proteases. Bioorg Med Chem 13:257-64 (2005) [PubMed]  Article 
Target
Name:
Genome polyprotein [1424-1463]/[1502-1685]
Synonyms:
WNV CF40.Gly.NS3Pro | WNV NS2B(H):NS3 | West Nile Virus (WNV) NS2B-NS3 Protease
Type:
Cofactor/Enzyme
Mol. Mass.:
n/a
Description:
It is the catalytically active recombinant WNV protease, consisting of a 40-residue component of cofactor NS2B tethered via a nonapeptide (G4SG4) to the N-terminal 184 residues of NS3.
Components:
This complex has 2 components.
Component 1
Name:
Genome polyprotein [1424-1463]
Synonyms:
Flavivirin protease NS2B regulatory subunit | NS2B | POLG_WNV
Type:
Cofactor Domain
Mol. Mass.:
4431.59
Organism:
West Nile virus (WNV)
Description:
P06935[1424-1463]
Residue:
40
Sequence:
IERTADITWESDAEITGSSERVDVRLDDDGNFQLMNDPGA
  
Component 2
Name:
Genome polyprotein [1502-1685]
Synonyms:
Flavivirin protease NS3 catalytic subunit | NS3 | POLG_WNV
Type:
Catalytic Subunit
Mol. Mass.:
19839.27
Organism:
West Nile virus (WNV)
Description:
P06935[1502-1685]
Residue:
184
Sequence:
GGVLWDTPSPKEYKKGDTTTGVYRIMTRGLLGSYQAGAGVMVEGVFHTLWHTTKGAALMSGEGRLDPYWGSVKEDRLCYGGPWKLQHKWNGHDEVQMIVVEPGKNVKNVQTKPGVFKTPEGEIGAVTLDYPTGTSGSPIVDKNGDVIGLYGNGVIMPNGSYISAIVQGERMEEPAPAGFEPEML
  
Inhibitor
Name:
BDBM33265
Synonyms:
guanidine, 5
Type:
Small organic molecule
Emp. Form.:
C9H13N4O2P
Mol. Mass.:
240.1989
SMILES:
[#6]-c1ccc(cc1)-[#6](=[#7]\[#7]=[#6](\[#7])-[#7])-[#15](-[#8])-[#8] |w:8.9|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM33263
Synonyms:
AMC, 7-amido-4-methylcoumarin | Boc-Gly-Arg-Arg-AMC
Type:
fluorogenic peptide substrate
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
n/a
Structure: