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Target
Isoform 7 of cAMP-specific 3',5'-cyclic phosphodiesterase 4A (PDE4A8)
Ligand
BDBM399978
Substrate
n/a
Meas. Tech.
cintillation Proximity Assay (SPA)
IC50
1.86±n/a nM
Citation
 Chappie, TA; Patel, NC; Verhoest, PR; Helal, CJ; Sciabola, S; LaChapelle, EA; Wager, TT; Hayward, MM 6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-2-carboxamide compounds US Patent  US10323042 Publication Date 6/18/2019 
Target
Name:
Isoform 7 of cAMP-specific 3',5'-cyclic phosphodiesterase 4A (PDE4A8)
Synonyms:
DPDE2 | NP_001104779 | PDE4A | PDE4A3 | PDE4A_HUMAN | cAMP-specific 3',5'-cyclic phosphodiesterase 4A (PDE4A8) | cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
91289.34
Organism:
Homo sapiens (Human)
Description:
P27815-7
Residue:
825
Sequence:
MRSGAAPRARPRPPALALPPTGPESLTHFPFSDEDTRRHPPGRSVSFEAENGPTPSPGRSPLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGGGSGGDPT
  
Inhibitor
Name:
BDBM399978
Synonyms:
US10323042, Example 57 | US10738063, Example 57
Type:
Small organic molecule
Emp. Form.:
C17H16ClF2N3O2
Mol. Mass.:
367.778
SMILES:
Cc1cc(Cl)c(F)cc1-c1c(nn2C[C@H](F)COc12)C(=O)NC1CC1 |r,wD:14.15,(-2.49,.88,;-1,1.28,;-.6,2.76,;.88,3.16,;1.28,4.65,;1.97,2.07,;3.46,2.47,;1.57,.59,;.09,.19,;-.31,-1.3,;.59,-2.55,;-.31,-3.79,;-1.78,-3.32,;-3.11,-4.09,;-4.44,-3.32,;-5.78,-4.09,;-4.44,-1.78,;-3.11,-1.01,;-1.78,-1.78,;2.13,-2.55,;2.9,-1.21,;2.9,-3.88,;4.44,-3.88,;5.78,-4.65,;5.78,-3.11,)|
Structure:
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