Target

Ligand

Substrate

Meas. Tech.

In Vitro BRAF Kinase Assay

Citation

 Smith, AL; DeMorin, FF; Paras, NA; Huang, Q; Petkus, JK; Doherty, EM; Nixey, T; Kim, JL; Whittington, DA; Epstein, LF; Lee, MR; Rose, MJ; Babij, C; Fernando, M; Hess, K; Le, Q; Beltran, P; Carnahan, J Selective inhibitors of the mutant B-Raf pathway: discovery of a potent and orally bioavailable aminoisoquinoline. J Med Chem 52:6189-92 (2009) [PubMed]  Article Copy BDB DOI

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Name:

Tyrosine-protein kinase Lck

Synonyms:

2.7.10.2 | LCK | LCK_HUMAN | LSK | Leukocyte C-terminal Src kinase | Lymphocyte cell-specific protein-tyrosine kinase | Lymphocyte-specific protein tyrosine kinase | P56-LCK | Protein YT16 | Proto-oncogene Lck | Proto-oncogene tyrosine-protein kinase LCK | Src/Lck kinase | T cell-specific protein-tyrosine kinase

Type:

n/a

Mol. Mass.:

57987.83

Organism:

Homo sapiens (Human)

Description:

P06239

Residue:

509

Sequence:

MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP

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Blast E-value cutoff:

Name:

BDBM35317

Synonyms:

4-Methyl-3-(2-(methylamino)quinazolin-6-yl)-N-(3-(trifluoromethyl)phenyl)benzamide | CHEMBL212964 | aminoquinazoline benzamide, 3

Type:

Small organic molecule

Emp. Form.:

C24H19F3N4O

Mol. Mass.:

436.4291

SMILES:

CNc1ncc2cc(ccc2n1)-c1cc(ccc1C)C(=O)Nc1cccc(c1)C(F)(F)F

Structure:

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Similarity to this molecule at least:

Name:

Gastrin Peptide Substrate

Synonyms:

Biotinylated gastrin peptide substrate | biotinylated gastrin substrate | gastrin substrate

Type:

Peptide

Mol. Mass.:

1823.88

Organism:

n/a

Description:

n/a

Residue:

15

Sequence:

ITINEEEEAYGWLDF