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Target
Dual specificity protein phosphatase 1
Ligand
BDBM31040
Substrate
OMFP Substrate
Meas. Tech.
In vitro MKP-1 Phosphatase HTS Dose Response Confirmation Assay
pH
7±n/a
Temperature
295.15±n/a K
IC50
197±n/a nM
Citation
 PubChem, PC In vitro MKP-1 Phosphatase HTS Dose Response Confirmation Assay PubChem Bioassay (2007)[AID] 
Target
Name:
Dual specificity protein phosphatase 1
Synonyms:
CL100 | DUS1_HUMAN | DUSP1 | Dual specificity protein phosphatase hVH1 | MAP kinase phosphatase 1 | MKP-1 | MKP1 | PTPN10 | Protein-tyrosine phosphatase CL100 | VH1
Type:
Protein phosphatase
Mol. Mass.:
39301.48
Organism:
Homo sapiens (Human)
Description:
gi_4758204
Residue:
367
Sequence:
MVMEVGTLDAGGLRALLGERAAQCLLLDCRSFFAFNAGHIAGSVNVRFSTIVRRRAKGAMGLEHIVPNAELRGRLLAGAYHAVVLLDERSAALDGAKRDGTLALAAGALCREARAAQVFFLKGGYEAFSASCPELCSKQSTPMGLSLPLSTSVPDSAESGCSSCSTPLYDQGGPVEILPFLYLGSAYHASRKDMLDALGITALINVSANCPNHFEGHYQYKSIPVEDNHKADISSWFNEAIDFIDSIKNAGGRVFVHCQAGISRSATICLAYLMRTNRVKLDEAFEFVKQRRSIISPNFSFMGQLLQFESQVLAPHCSAEAGSPAMAVLDRGTSTTTVFNFPVSIPVHSTNSALSYLQSPITTSPSC
  
Inhibitor
Name:
BDBM31040
Synonyms:
1-Ethyl-6-methyl-3-phenyl-1H-pyrimido[5,4-e][1,2,4]triazine-5,7-dione | 1-ethyl-6-methyl-3-phenyl-pyrimido[5,4-e][1,2,4]triazine-5,7-dione | 1-ethyl-6-methyl-3-phenyl-pyrimido[5,4-e][1,2,4]triazine-5,7-quinone | 1-ethyl-6-methyl-3-phenylpyrimido[5,4-e][1,2,4]triazine-5,7-dione | MLS000027832 | SMR000008919 | US9073941, 602 | cid_647501
Type:
Small organic molecule
Emp. Form.:
C14H13N5O2
Mol. Mass.:
283.2853
SMILES:
CCn1nc(nc2c1nc(=O)n(C)c2=O)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
OMFP Substrate
Synonyms:
3-O-methylfluorescein phosphate | OMFP
Type:
fluorescent substrate
Mol. Mass.:
358.43
Organism:
n/a
Description:
n/a
Residue:
3
Sequence:
NA