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Target
Dual specificity protein phosphatase 1
Ligand
BDBM35443
Substrate
OMFP Substrate
Meas. Tech.
In vitro MKP-1 Phosphatase Dose Response SAR Support Assay
pH
7±n/a
Temperature
296.15±n/a K
IC50
>50000±n/a nM
Citation
 PubChem, PC In vitro MKP-1 Phosphatase Dose Response SAR Support Assay  PubChem Bioassay (2007)[AID] 
Target
Name:
Dual specificity protein phosphatase 1
Synonyms:
CL100 | DUS1_HUMAN | DUSP1 | Dual specificity protein phosphatase hVH1 | MAP kinase phosphatase 1 | MKP-1 | MKP1 | PTPN10 | Protein-tyrosine phosphatase CL100 | VH1
Type:
Protein phosphatase
Mol. Mass.:
39301.48
Organism:
Homo sapiens (Human)
Description:
gi_4758204
Residue:
367
Sequence:
MVMEVGTLDAGGLRALLGERAAQCLLLDCRSFFAFNAGHIAGSVNVRFSTIVRRRAKGAMGLEHIVPNAELRGRLLAGAYHAVVLLDERSAALDGAKRDGTLALAAGALCREARAAQVFFLKGGYEAFSASCPELCSKQSTPMGLSLPLSTSVPDSAESGCSSCSTPLYDQGGPVEILPFLYLGSAYHASRKDMLDALGITALINVSANCPNHFEGHYQYKSIPVEDNHKADISSWFNEAIDFIDSIKNAGGRVFVHCQAGISRSATICLAYLMRTNRVKLDEAFEFVKQRRSIISPNFSFMGQLLQFESQVLAPHCSAEAGSPAMAVLDRGTSTTTVFNFPVSIPVHSTNSALSYLQSPITTSPSC
  
Inhibitor
Name:
BDBM35443
Synonyms:
6-amino-5-(2-chloro-1-oxoethyl)-3-methyl-1-(2-methylpropyl)pyrimidine-2,4-dione | 6-amino-5-(2-chloroacetyl)-1-isobutyl-3-methyl-pyrimidine-2,4-quinone | 6-amino-5-(2-chloroacetyl)-3-methyl-1-(2-methylpropyl)pyrimidine-2,4-dione | 6-azanyl-5-(2-chloranylethanoyl)-3-methyl-1-(2-methylpropyl)pyrimidine-2,4-dione | CC-PMLSC-DMA-P92 | cid_2490478
Type:
Small organic molecule
Emp. Form.:
C11H16ClN3O3
Mol. Mass.:
273.716
SMILES:
CC(C)Cn1c(N)c(C(=O)CCl)c(=O)n(C)c1=O
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
OMFP Substrate
Synonyms:
3-O-methylfluorescein phosphate | OMFP
Type:
fluorescent substrate
Mol. Mass.:
358.43
Organism:
n/a
Description:
n/a
Residue:
3
Sequence:
NA