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Target
Dual specificity protein phosphatase 1
Ligand
BDBM35456
Substrate
OMFP Substrate
Meas. Tech.
In vitro MKP-1 Phosphatase Dose Response SAR Support Assay
pH
7±n/a
Temperature
296.15±n/a K
IC50
>50000±n/a nM
Citation
 PubChem, PC In vitro MKP-1 Phosphatase Dose Response SAR Support Assay  PubChem Bioassay (2007)[AID] 
Target
Name:
Dual specificity protein phosphatase 1
Synonyms:
CL100 | DUS1_HUMAN | DUSP1 | Dual specificity protein phosphatase hVH1 | MAP kinase phosphatase 1 | MKP-1 | MKP1 | PTPN10 | Protein-tyrosine phosphatase CL100 | VH1
Type:
Protein phosphatase
Mol. Mass.:
39301.48
Organism:
Homo sapiens (Human)
Description:
gi_4758204
Residue:
367
Sequence:
MVMEVGTLDAGGLRALLGERAAQCLLLDCRSFFAFNAGHIAGSVNVRFSTIVRRRAKGAMGLEHIVPNAELRGRLLAGAYHAVVLLDERSAALDGAKRDGTLALAAGALCREARAAQVFFLKGGYEAFSASCPELCSKQSTPMGLSLPLSTSVPDSAESGCSSCSTPLYDQGGPVEILPFLYLGSAYHASRKDMLDALGITALINVSANCPNHFEGHYQYKSIPVEDNHKADISSWFNEAIDFIDSIKNAGGRVFVHCQAGISRSATICLAYLMRTNRVKLDEAFEFVKQRRSIISPNFSFMGQLLQFESQVLAPHCSAEAGSPAMAVLDRGTSTTTVFNFPVSIPVHSTNSALSYLQSPITTSPSC
  
Inhibitor
Name:
BDBM35456
Synonyms:
CC-PMLSC-DMA-P128 | N'-(2,6-diketo-3-methyl-pyrimidin-4-yl)-N,N-dimethyl-formamidine | N,N-dimethyl-N'-(3-methyl-2,6-dioxo-4-pyrimidinyl)methanimidamide | N,N-dimethyl-N'-(3-methyl-2,6-dioxopyrimidin-4-yl)methanimidamide | N,N-dimethyl-N'-[3-methyl-2,6-bis(oxidanylidene)pyrimidin-4-yl]methanimidamide | cid_9547714
Type:
Small organic molecule
Emp. Form.:
C8H12N4O2
Mol. Mass.:
196.2065
SMILES:
CN(C)C=Nc1cc(=O)[nH]c(=O)n1C |w:4.4|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
OMFP Substrate
Synonyms:
3-O-methylfluorescein phosphate | OMFP
Type:
fluorescent substrate
Mol. Mass.:
358.43
Organism:
n/a
Description:
n/a
Residue:
3
Sequence:
NA