Reaction Details Report a problem with these data
Target
Cathepsin B
Ligand
BDBM35487
Substrate
Z-Arg-Arg-AMC
Meas. Tech.
Cathepsin B mixture HTS dose-response confirmation
pH
6.8±n/a
Temperature
296.15±n/a K
IC50
6355.62±n/a nM
Citation
 PubChem, PC Cathepsin B mixture HTS dose-response confirmation  PubChem Bioassay (2008)[AID] 
Target
Name:
Cathepsin B
Synonyms:
APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1
Type:
Enzyme
Mol. Mass.:
37819.69
Organism:
Homo sapiens (Human)
Description:
gi_63102437
Residue:
339
Sequence:
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
  
Inhibitor
Name:
BDBM35487
Synonyms:
2-thiophenecarboxylic acid [2-oxo-1-(2-pyridinyl)-2-(thiophen-2-ylmethylamino)ethyl] ester | MLS000075019 | SMR000008036 | Thiophene-2-carboxylic acid pyridin-2-yl-[(thiophen-2-ylmethyl)-carbamoyl]-methyl ester | [2-oxidanylidene-1-pyridin-2-yl-2-(thiophen-2-ylmethylamino)ethyl] thiophene-2-carboxylate | [2-oxo-1-pyridin-2-yl-2-(thiophen-2-ylmethylamino)ethyl] thiophene-2-carboxylate | cid_648315 | thiophene-2-carboxylic acid [2-keto-1-(2-pyridyl)-2-(2-thenylamino)ethyl] ester
Type:
Small organic molecule
Emp. Form.:
C17H14N2O3S2
Mol. Mass.:
358.435
SMILES:
O=C(NCc1cccs1)C(OC(=O)c1cccs1)c1ccccn1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Z-Arg-Arg-AMC
Synonyms:
Benzyloxycarbonyl- L-arginyl- L-arginine- 4-methylcoumaryl-7-amide
Type:
fluorogenic substrate
Mol. Mass.:
358.43
Organism:
n/a
Description:
n/a
Residue:
3
Sequence:
NA