Target
Cathepsin B
Ligand
BDBM35489
Substrate
Z-Arg-Arg-AMC
Meas. Tech.
Cathepsin B mixture HTS dose-response confirmation
pH
6.8±n/a
Temperature
296.15±n/a K
IC50
2120.02±n/a nM
Citation
 PubChem, PC Cathepsin B mixture HTS dose-response confirmation  PubChem Bioassay (2008)[AID] 
Target
Name:
Cathepsin B
Synonyms:
APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1
Type:
Enzyme
Mol. Mass.:
37819.69
Organism:
Homo sapiens (Human)
Description:
gi_63102437
Residue:
339
Sequence:
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
  
Inhibitor
Name:
BDBM35489
Synonyms:
1-Acetyl-3-(3,4-dichloro-5-oxo-2,5-dihydro-furan-2-yl)-urea | MLS000035450 | N-[(3,4-dichloro-5-keto-2H-furan-2-yl)carbamoyl]acetamide | N-[(3,4-dichloro-5-oxo-2H-furan-2-yl)carbamoyl]acetamide | N-[[(3,4-dichloro-5-oxo-2H-furan-2-yl)amino]-oxomethyl]acetamide | N-[[3,4-bis(chloranyl)-5-oxidanylidene-2H-furan-2-yl]carbamoyl]ethanamide | SMR000001295 | cid_654815
Type:
Small organic molecule
Emp. Form.:
C7H6Cl2N2O4
Mol. Mass.:
253.04
SMILES:
CC(=O)NC(=O)NC1OC(=O)C(Cl)=C1Cl |c:12|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Z-Arg-Arg-AMC
Synonyms:
Benzyloxycarbonyl- L-arginyl- L-arginine- 4-methylcoumaryl-7-amide
Type:
fluorogenic substrate
Mol. Mass.:
358.43
Organism:
n/a
Description:
n/a
Residue:
3
Sequence:
NA