Reaction Details Report a problem with these data
Target
Cathepsin B
Ligand
BDBM35504
Substrate
Z-Arg-Arg-AMC
Meas. Tech.
Cathepsin B mixture HTS dose-response confirmation
pH
6.8±n/a
Temperature
296.15±n/a K
IC50
>50000±n/a nM
Citation
 PubChem, PC Cathepsin B mixture HTS dose-response confirmation  PubChem Bioassay (2008)[AID] 
Target
Name:
Cathepsin B
Synonyms:
APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1
Type:
Enzyme
Mol. Mass.:
37819.69
Organism:
Homo sapiens (Human)
Description:
gi_63102437
Residue:
339
Sequence:
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
  
Inhibitor
Name:
BDBM35504
Synonyms:
2-(N-(3,5-dimethylisoxazol-4-yl)sulfonyl-4-methoxy-anilino)-N-(tetrahydrofurfuryl)acetamide | 2-[(3,5-dimethyl-1,2-oxazol-4-yl)sulfonyl-(4-methoxyphenyl)amino]-N-(oxolan-2-ylmethyl)ethanamide | 2-[N-[(3,5-dimethyl-1,2-oxazol-4-yl)sulfonyl]-4-methoxyanilino]-N-(oxolan-2-ylmethyl)acetamide | 2-[N-[(3,5-dimethyl-4-isoxazolyl)sulfonyl]-4-methoxyanilino]-N-(2-oxolanylmethyl)acetamide | MLS000092333 | N~2~-[(3,5-dimethylisoxazol-4-yl)sulfonyl]-N~2~-(4-methoxyphenyl)-N~1~-(tetrahydrofuran-2-ylmethyl)glycinamide | SMR000027410 | cid_3236935
Type:
Small organic molecule
Emp. Form.:
C19H25N3O6S
Mol. Mass.:
423.483
SMILES:
COc1ccc(cc1)N(CC(=O)NCC1CCCO1)S(=O)(=O)c1c(C)noc1C
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Z-Arg-Arg-AMC
Synonyms:
Benzyloxycarbonyl- L-arginyl- L-arginine- 4-methylcoumaryl-7-amide
Type:
fluorogenic substrate
Mol. Mass.:
358.43
Organism:
n/a
Description:
n/a
Residue:
3
Sequence:
NA