Reaction Details Report a problem with these data
Target
Cathepsin B
Ligand
BDBM35522
Substrate
Z-Arg-Arg-AMC
Meas. Tech.
Cathepsin B mixture HTS dose-response confirmation
pH
6.8±n/a
Temperature
296.15±n/a K
IC50
12947.1±n/a nM
Citation
 PubChem, PC Cathepsin B mixture HTS dose-response confirmation  PubChem Bioassay (2008)[AID] 
Target
Name:
Cathepsin B
Synonyms:
APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1
Type:
Enzyme
Mol. Mass.:
37819.69
Organism:
Homo sapiens (Human)
Description:
gi_63102437
Residue:
339
Sequence:
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
  
Inhibitor
Name:
BDBM35522
Synonyms:
2-spiro[5,6,7,8-tetrahydro-1H-[1,2,4]triazolo[5,1-b]quinazoline-9,1'-cyclohexane]amine | MLS000111227 | SMR000107153 | cid_5310676 | spiro[5,6,7,8-tetrahydro-1H-[1,2,4]triazolo[5,1-b]quinazoline-9,1'-cyclohexane]-2-amine | spiro[5,6,7,8-tetrahydro-1H-[1,2,4]triazolo[5,1-b]quinazoline-9,1'-cyclohexane]-2-ylamine
Type:
Small organic molecule
Emp. Form.:
C14H21N5
Mol. Mass.:
259.35
SMILES:
Nc1nc2N=C3CCCCC3C3(CCCCC3)n2n1 |t:4|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Z-Arg-Arg-AMC
Synonyms:
Benzyloxycarbonyl- L-arginyl- L-arginine- 4-methylcoumaryl-7-amide
Type:
fluorogenic substrate
Mol. Mass.:
358.43
Organism:
n/a
Description:
n/a
Residue:
3
Sequence:
NA