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TargetMitogen-activated protein kinase 1
LigandBDBM35642
Substrate/Competitorerktide
Meas. Tech.Ki Determination
pH7.5±n/a
Temperature303.15±n/a K
Ki<2±n/a nM
Citation Aronov, AMTang, QMartinez-Botella, GBemis, GWCao, JChen, GEwing, NPFord, PJGermann, UAGreen, JHale, MRJacobs, MJanetka, JWMaltais, FMarkland, WNamchuk, MNNanthakumar, SPoondru, SStraub, Jter Haar, EXie, X Structure-guided design of potent and selective pyrimidylpyrrole inhibitors of extracellular signal-regulated kinase (ERK) using conformational control. J Med Chem52:6362-8 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Mitogen-activated protein kinase 1
Name:Mitogen-activated protein kinase 1
Synonyms:ERK2 | ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK-2) | Extracellular signal-regulated kinase 2 (ERK2) | MAP Kinase 2/ERK2 | MAPK 2 | MAPK1 | Mitogen activated kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK2) | Mitogen-activated protein kinase 2 | p42-MAPK
Type:Ser/Thr Protein Kinase
Mol. Mass.:41392.76
Organism:Homo sapiens (Human)
Description:P28482
Residue:360
Sequence:
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFE
HQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQH
LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDH
TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI
LGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHK
RIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM35642
NameBDBM35642
Synonyms:pyrimidylpyrrole, 9a
TypeSmall organic molecule
Emp. Form.C24H22ClN5O2
Mol. Mass.447.917
SMILESCc1cnc(Nc2ccccc2Cl)nc1-c1c[nH]c(c1)C(=O)N[C@H](CO)c1ccccc1 |r|
Structure
erktide
Name:ERKtide
Synonyms:n/a
Type:Peptide
Mol. Mass.:1314.49
Organism:n/a
Description:n/a
Residue:13
Sequence:
ATGPLSPGPFGRR