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Target
Calcium-dependent protein kinase 1
Ligand
BDBM22985
Substrate
MTIP
Meas. Tech.
Parasite Proliferation Assay
pH
7.5±0
Temperature
297.15±0 K
EC50
68±0 nM
Citation
 Kato, N; Sakata, T; Breton, G; Le Roch, KG; Nagle, A; Andersen, C; Bursulaya, B; Henson, K; Johnson, J; Kumar, KA; Marr, F; Mason, D; McNamara, C; Plouffe, D; Ramachandran, V; Spooner, M; Tuntland, T; Zhou, Y; Peters, EC; Chatterjee, A; Schultz, PG; Ward, GE; Gray, N; Harper, J; Winzeler, EA Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility. Nat Chem Biol 4:347-56 (2008) [PubMed]  Article 
Target
Name:
Calcium-dependent protein kinase 1
Synonyms:
CDPK1 | CDPK1_PLAFK | CPK1 | Calcium-dependent protein kinase 1 | PfCDPK1
Type:
PROTEIN
Mol. Mass.:
60804.87
Organism:
Plasmodium Falciparum
Description:
P62343
Residue:
524
Sequence:
MGCSQSSNVKDFKTRRSKFTNGNNYGKSGNNKNSEDLAINPGMYVRKKEGKIGESYFKVRKLGSGAYGEVLLCREKHGHGEKAIKVIKKSQFDKMKYSITNKIECDDKIHEEIYNEISLLKSLDHPNIIKLFDVFEDKKYFYLVTEFYEGGELFEQIINRHKFDECDAANIMKQILSGICYLHKHNIVHRDIKPENILLENKHSLLNIKIVDFGLSSFFSKDNKLRDRLGTAYYIAPEVLRKKYNEKCDVWSCGVILYILLCGYPPFGGQNDQDIIKKVEKGKYYFDFNDWKNISEEAKELIKLMLTYDYNKRITAKEALNSKWIKKYANNINKSDQKTLCGALSNMRKFEGSQKLAQAAILFIGSKLTTLEERKELTDIFKKLDKNGDGQLDKKELIEGYNILRSFKNELGELKNVEEEVDNILKEVDFDKNGYIEYSEFISVCMDKQILFSEERLRDAFNLFDTDKSGKITKEELANLFGLTSISEQMWNEVLGEADKNKDNMIDFDEFVNMMHKICDNKSS
  
Inhibitor
Name:
BDBM22985
Synonyms:
Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chlorochin | Chloroquine | Chloroquine, 17 | med.21724, Compound 8 | {4-[(7-chloroquinolin-4-yl)amino]pentyl}diethylamine
Type:
Antimalarial
Emp. Form.:
C18H26ClN3
Mol. Mass.:
319.872
SMILES:
CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
MTIP
Synonyms:
PFL2225w
Type:
Substrate
Mol. Mass.:
23466.36
Organism:
Plasmodium falciparum
Description:
Q8I4W8
Residue:
204
Sequence:
MKQECNVCYFNLPDPESTLGPYDNELNYFTWGPGFEYEPEPQRKPLSIEESFENSEESEESVADIQQLEEKVDESDVRIYFNEKSSGGKISIDNASYNARKLGLAPSSIDEKKIKELYGDNLTYEQYLEYLSICVHDKDNVEELIKMFAHFDNNCTGYLTKSQMKNILTTWGDALTDQEAIDALNAFSSEDNIDYKLFCEDILQ