Target
Receptor protein serine/threonine kinase
Ligand
BDBM50262685
Substrate
poly(Glu4, Tyr)
Meas. Tech.
Kinase assay Dorsalization
EC50
2.5e+3±n/a nM
Citation
 Hao, JHo, JNLewis, JAKarim, KADaniels, RNGentry, PRHopkins, CRLindsley, CWHong, CC In vivo structure-activity relationship study of dorsomorphin analogues identifies selective VEGF and BMP inhibitors. ACS Chem Biol 5:245-53 (2010) [PubMed]  Article 
Target
Name:
Receptor protein serine/threonine kinase
Synonyms:
B3DJG0 | BMP | Bmpr1a protein | Bone morphogenetic protein
Type:
n/a
Mol. Mass.:
59502.00
Organism:
Danio rerio (Zebrafish)
Description:
B3DJG0
Residue:
526
Sequence:
MRQLLFITVVLTGVCLLLTLCSGGQNPDHVLQGTGVKLDSRRPGDDSTIAPEDAARFLSCHCSGHCPDDAKNNTCETNGQCFAIIEEDENGDVILSSGCMKYEGSHFQCKDSQFAQTRRTIECCQFDFCNQDLKPELPPRDSEPPDPHWLAFLISVTVCFCALICVTVICYYRYKWQTERQRYHRDLEQDEAFIPAGESLKDLINQSQTSGSGSGLPLLVQRTIAKQIQTVRMIGKGRYGEVWLGRWRGEKVAVKVFFTREEASWFRETEIYQTVLMRHENILGFIAADINGTGASTQLYLITDYHENGSLYDYLKFTTLDTQALLRLAFSAACGLCHLHTEIYGTQGKPAIAHRDLKSKNILIKKNGTCCIADLGLAVKFNSDTNEVDLPLSTRMGTRRYMAPEVLDETLNKNHFQAYIMADIYSYGLVIWEMARRCVTGGIVEEYQLPYYEMVPSDPSYEDMLEVVCVKGLRPTVSNRWNSDECLRAMLKLMSECWAHNPASRLTILRVKKTLAKMVESQDIKI
  
Inhibitor
Name:
BDBM50262685
Synonyms:
6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine | 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine | CHEMBL478629 | Dorsomorphin | US9040694, Dorsomorphin
Type:
Small organic molecule
Emp. Form.:
C24H25N5O
Mol. Mass.:
399.4882
SMILES:
C(CN1CCCCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccncc1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
poly(Glu4, Tyr)
Synonyms:
n/a
Type:
Random copolymer
Mol. Mass.:
358.43
Organism:
n/a
Description:
n/a
Residue:
3
Sequence:
NA