Target
Adenosylhomocysteine nucleosidase
Ligand
BDBM36498
Substrate
BDBM22111
Meas. Tech.
Enzyme Activity Assay
pH
7.5±0
Temperature
298.15±0 K
Kd
0.570±0.0 nM
Citation
 Gutierrez, JALuo, MSingh, VLi, LBrown, RLNorris, GEEvans, GBFurneaux, RHTyler, PCPainter, GFLenz, DHSchramm, VL Picomolar inhibitors as transition-state probes of 5'-methylthioadenosine nucleosidases. ACS Chem Biol 2:725-34 (2007) [PubMed]  Article 
Target
Name:
Adenosylhomocysteine nucleosidase
Synonyms:
5'-methylthioadenosine nucleosidase | MTN | Methylthioadenosine Nucleosidase (MTAN)
Type:
Enzyme
Mol. Mass.:
25233.34
Organism:
Helicobacter pylori
Description:
D0IQW9
Residue:
231
Sequence:
MVQKIGILGAMREEITPILELFGVDFEEIPLGGNVFHKGVYHDKEIIVAYSKIGKVHSTLTTTSMILAFGVQKVLFSGVAGSLNKDLKINDLLVAIQLVQHDVDLSAFNHPLGFIPESAIFIETSESLNALAKKVANEQHITLKEGVIASGDQFVHSKERKEFLISEFKASAVEMEGASVAFVCQKFGVPCCVLRSISDNADEEANMSFDAFLEKSAQTSAKFLKSMVDKL
  
Inhibitor
Name:
BDBM36498
Synonyms:
DADMe-ImmA-p-ClPh
Type:
Small organic molecule
Emp. Form.:
C18H20ClN5OS
Mol. Mass.:
389.902
SMILES:
Nc1ncnc2c(CN3CC(O)C(CSc4ccc(Cl)cc4)C3)c[nH]c12
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM22111
Synonyms:
(2R,3R,4S,5S)-2-(6-amino-9H-purin-9-yl)-5-[(methylsulfanyl)methyl]oxolane-3,4-diol | (2R,3R,4S,5S)-2-(6-aminopurin-9-yl)-5-(methylsulfanylmethyl)oxolane-3,4-diol | 5'-Methylthioado | 5-methylthioadenosine | CHEMBL277041 | MTA
Type:
Nucleoside or nucleotide
Emp. Form.:
C11H15N5O3S
Mol. Mass.:
297.334
SMILES:
CSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Structure:
Search PDB for entries with ligand similarity: