Reaction Details Report a problem with these data
Target
Sphingosine 1-phosphate receptor 3
Ligand
BDBM37321
Substrate
n/a
Meas. Tech.
S1P3 Agonist Dose-Response Potency Assay
EC50
15300±n/a nM
Citation
 PubChem, PC S1P3 Agonist Dose-Response Potency Assay PubChem Bioassay (2007)[AID] 
Target
Name:
Sphingosine 1-phosphate receptor 3
Synonyms:
C9orf108 | C9orf47 | EDG3 | Endothelial differentiation G-protein coupled receptor 3 | S1P receptor 3 | S1P receptor Edg-3 | S1P3 | S1PR3 | S1PR3_HUMAN | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor 3 (S1P3) | Sphingosine 1-phosphate receptor Edg-3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42278.13
Organism:
Homo sapiens (Human)
Description:
Q99500
Residue:
378
Sequence:
MATALPPRLQPVRGNETLREHYQYVGKLAGRLKEASEGSTLTTVLFLVICSFIVLENLMVLIAIWKNNKFHNRMYFFIGNLALCDLLAGIAYKVNILMSGKKTFSLSPTVWFLREGSMFVALGASTCSLLAIAIERHLTMIKMRPYDANKRHRVFLLIGMCWLIAFTLGALPILGWNCLHNLPDCSTILPLYSKKYIAFCISIFTAILVTIVILYARIYFLVKSSSRKVANHNNSERSMALLRTVVIVVSVFIACWSPLFILFLIDVACRVQACPILFKAQWFIVLAVLNSAMNPVIYTLASKEMRRAFFRLVCNCLVRGRGARASPIQPALDPSRSKSSSSNNSSHSPKVKEDLPHTAPSSCIMDKNAALQNGIFCN
  
Inhibitor
Name:
BDBM37321
Synonyms:
2-(3,5-dimethyl-1-pyrazolyl)-6,6-dimethyl-N-(3-pyridinylmethyl)-5,8-dihydropyrano[4,5]thieno[1,2-c]pyrimidin-4-amine | 2-(3,5-dimethylpyrazol-1-yl)-6,6-dimethyl-N-(pyridin-3-ylmethyl)-5,8-dihydropyrano[4,5]thieno[1,2-c]pyrimidin-4-amine | MLS000082981 | SMR000046754 | [2-(3,5-dimethylpyrazol-1-yl)-6,6-dimethyl-5,8-dihydropyrano[4,5]thieno[1,2-c]pyrimidin-4-yl]-(3-pyridylmethyl)amine | cid_665690
Type:
Small organic molecule
Emp. Form.:
C22H24N6OS
Mol. Mass.:
420.531
SMILES:
Cc1cc(C)n(n1)-c1nc(NCc2cccnc2)c2c3CC(C)(C)OCc3sc2n1
Structure:
Search PDB for entries with ligand similarity: