Reaction Details Report a problem with these data
Target
Sphingosine 1-phosphate receptor 3
Ligand
BDBM37346
Substrate
n/a
Meas. Tech.
S1P3 Agonist Dose-Response Potency Assay
EC50
30800±n/a nM
Citation
 PubChem, PC S1P3 Agonist Dose-Response Potency Assay PubChem Bioassay (2007)[AID] 
Target
Name:
Sphingosine 1-phosphate receptor 3
Synonyms:
C9orf108 | C9orf47 | EDG3 | Endothelial differentiation G-protein coupled receptor 3 | S1P receptor 3 | S1P receptor Edg-3 | S1P3 | S1PR3 | S1PR3_HUMAN | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor 3 (S1P3) | Sphingosine 1-phosphate receptor Edg-3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42278.13
Organism:
Homo sapiens (Human)
Description:
Q99500
Residue:
378
Sequence:
MATALPPRLQPVRGNETLREHYQYVGKLAGRLKEASEGSTLTTVLFLVICSFIVLENLMVLIAIWKNNKFHNRMYFFIGNLALCDLLAGIAYKVNILMSGKKTFSLSPTVWFLREGSMFVALGASTCSLLAIAIERHLTMIKMRPYDANKRHRVFLLIGMCWLIAFTLGALPILGWNCLHNLPDCSTILPLYSKKYIAFCISIFTAILVTIVILYARIYFLVKSSSRKVANHNNSERSMALLRTVVIVVSVFIACWSPLFILFLIDVACRVQACPILFKAQWFIVLAVLNSAMNPVIYTLASKEMRRAFFRLVCNCLVRGRGARASPIQPALDPSRSKSSSSNNSSHSPKVKEDLPHTAPSSCIMDKNAALQNGIFCN
  
Inhibitor
Name:
BDBM37346
Synonyms:
MLS000106814 | SMR000111190 | [3-(2,6-dichlorophenyl)-5-methyl-1,2-oxazol-4-yl]-(2,3-dihydroindol-1-yl)methanone | [3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolyl]-(2,3-dihydroindol-1-yl)methanone | [3-(2,6-dichlorophenyl)-5-methyl-isoxazol-4-yl]-indolin-1-yl-methanone | [3-[2,6-bis(chloranyl)phenyl]-5-methyl-1,2-oxazol-4-yl]-(2,3-dihydroindol-1-yl)methanone | cid_1160933
Type:
Small organic molecule
Emp. Form.:
C19H14Cl2N2O2
Mol. Mass.:
373.233
SMILES:
Cc1onc(c1C(=O)N1CCc2ccccc12)-c1c(Cl)cccc1Cl |(10.17,-3.3,;10.33,-1.77,;11.67,-1,;11.35,.51,;9.82,.67,;9.19,-.73,;7.68,-1.05,;6.65,.1,;7.2,-2.51,;8.1,-3.75,;7.2,-4.99,;5.75,-4.52,;4.41,-5.29,;3.08,-4.52,;3.08,-2.98,;4.41,-2.21,;5.75,-2.98,;9.82,2.21,;8.49,2.99,;7.15,2.22,;8.49,4.53,;9.83,5.29,;11.16,4.52,;11.16,2.98,;12.49,2.21,)|
Structure:
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