Reaction Details Report a problem with these data
Target
Sphingosine 1-phosphate receptor 3
Ligand
BDBM37405
Substrate
n/a
Meas. Tech.
Dose Response Assay for S1P3 Antagonists
IC50
>49800±n/a nM
Citation
 PubChem, PC Dose Response Assay for S1P3 Antagonists PubChem Bioassay (2007)[AID] 
Target
Name:
Sphingosine 1-phosphate receptor 3
Synonyms:
C9orf108 | C9orf47 | EDG3 | Endothelial differentiation G-protein coupled receptor 3 | S1P receptor 3 | S1P receptor Edg-3 | S1P3 | S1PR3 | S1PR3_HUMAN | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor 3 (S1P3) | Sphingosine 1-phosphate receptor Edg-3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42278.13
Organism:
Homo sapiens (Human)
Description:
Q99500
Residue:
378
Sequence:
MATALPPRLQPVRGNETLREHYQYVGKLAGRLKEASEGSTLTTVLFLVICSFIVLENLMVLIAIWKNNKFHNRMYFFIGNLALCDLLAGIAYKVNILMSGKKTFSLSPTVWFLREGSMFVALGASTCSLLAIAIERHLTMIKMRPYDANKRHRVFLLIGMCWLIAFTLGALPILGWNCLHNLPDCSTILPLYSKKYIAFCISIFTAILVTIVILYARIYFLVKSSSRKVANHNNSERSMALLRTVVIVVSVFIACWSPLFILFLIDVACRVQACPILFKAQWFIVLAVLNSAMNPVIYTLASKEMRRAFFRLVCNCLVRGRGARASPIQPALDPSRSKSSSSNNSSHSPKVKEDLPHTAPSSCIMDKNAALQNGIFCN
  
Inhibitor
Name:
BDBM37405
Synonyms:
2-[[5-(2-bromophenyl)-4-keto-1H-pyrazolo[3,4-d]pyrimidin-6-yl]thio]-N-(2-furfuryl)acetamide | 2-[[5-(2-bromophenyl)-4-oxidanylidene-1H-pyrazolo[3,4-d]pyrimidin-6-yl]sulfanyl]-N-(furan-2-ylmethyl)ethanamide | 2-[[5-(2-bromophenyl)-4-oxo-1H-pyrazolo[3,4-d]pyrimidin-6-yl]sulfanyl]-N-(furan-2-ylmethyl)acetamide | 2-[[5-(2-bromophenyl)-4-oxo-1H-pyrazolo[3,4-d]pyrimidin-6-yl]thio]-N-(2-furanylmethyl)acetamide | 2-{[5-(2-bromophenyl)-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl]thio}-N-(2-furylmethyl)acetamide | MLS000095844 | SMR000031392 | cid_3238890
Type:
Small organic molecule
Emp. Form.:
C18H14BrN5O3S
Mol. Mass.:
460.304
SMILES:
Brc1ccccc1-n1c(SCC(=O)NCc2ccco2)nc2n[nH]cc2c1=O |(8.33,6.96,;6.99,6.19,;5.66,6.96,;4.33,6.19,;4.33,4.65,;5.66,3.88,;6.99,4.65,;8.33,3.88,;8.33,2.34,;6.99,1.57,;6.99,.03,;5.66,-.74,;4.33,.03,;5.66,-2.28,;4.33,-3.05,;4.33,-4.59,;3.08,-5.5,;3.56,-6.96,;5.1,-6.96,;5.57,-5.5,;9.66,1.57,;10.99,2.34,;12.45,1.87,;13.35,3.11,;12.45,4.35,;10.99,3.88,;9.66,4.65,;9.66,6.19,)|
Structure:
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