Reaction Details Report a problem with these data
Target
Sphingosine 1-phosphate receptor 3
Ligand
BDBM37513
Substrate
n/a
Meas. Tech.
Dose Response Assay for S1P3 Antagonists
IC50
22650±n/a nM
Citation
 PubChem, PC Dose Response Assay for S1P3 Antagonists PubChem Bioassay (2007)[AID] 
Target
Name:
Sphingosine 1-phosphate receptor 3
Synonyms:
C9orf108 | C9orf47 | EDG3 | Endothelial differentiation G-protein coupled receptor 3 | S1P receptor 3 | S1P receptor Edg-3 | S1P3 | S1PR3 | S1PR3_HUMAN | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor 3 (S1P3) | Sphingosine 1-phosphate receptor Edg-3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42278.13
Organism:
Homo sapiens (Human)
Description:
Q99500
Residue:
378
Sequence:
MATALPPRLQPVRGNETLREHYQYVGKLAGRLKEASEGSTLTTVLFLVICSFIVLENLMVLIAIWKNNKFHNRMYFFIGNLALCDLLAGIAYKVNILMSGKKTFSLSPTVWFLREGSMFVALGASTCSLLAIAIERHLTMIKMRPYDANKRHRVFLLIGMCWLIAFTLGALPILGWNCLHNLPDCSTILPLYSKKYIAFCISIFTAILVTIVILYARIYFLVKSSSRKVANHNNSERSMALLRTVVIVVSVFIACWSPLFILFLIDVACRVQACPILFKAQWFIVLAVLNSAMNPVIYTLASKEMRRAFFRLVCNCLVRGRGARASPIQPALDPSRSKSSSSNNSSHSPKVKEDLPHTAPSSCIMDKNAALQNGIFCN
  
Inhibitor
Name:
BDBM37513
Synonyms:
3-(2,5-dimethyl-1-pyrrolyl)-2-methyl-6-phenyl-4-thieno[2,3-d]pyrimidinone | 3-(2,5-dimethylpyrrol-1-yl)-2-methyl-6-phenyl-thieno[2,3-d]pyrimidin-4-one | 3-(2,5-dimethylpyrrol-1-yl)-2-methyl-6-phenylthieno[2,3-d]pyrimidin-4-one | MLS000113744 | SMR000109636 | cid_711116
Type:
Small organic molecule
Emp. Form.:
C19H17N3OS
Mol. Mass.:
335.423
SMILES:
Cc1ccc(C)n1-n1c(C)nc2sc(cc2c1=O)-c1ccccc1 |(6.5,2.82,;5.36,1.79,;3.85,2.11,;3.08,.78,;4.11,-.37,;3.79,-1.87,;5.52,.26,;6.85,-.51,;6.85,-2.05,;5.52,-2.82,;8.18,-2.82,;9.52,-2.05,;10.98,-2.52,;11.87,-1.28,;10.98,-.04,;9.52,-.51,;8.18,.26,;8.18,1.8,;13.41,-1.28,;14.18,-2.61,;15.72,-2.61,;16.49,-1.28,;15.72,.05,;14.18,.05,)|
Structure:
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