Reaction Details Report a problem with these data
Target
Cathepsin B
Ligand
BDBM37863
Substrate
n/a
Meas. Tech.
Cathepsin B Inhibitor Series SAR Study
IC50
>50000±0 nM
Citation
 PubChem, PC Cathepsin B Inhibitor Series SAR Study PubChem Bioassay (2008)[AID] 
Target
Name:
Cathepsin B
Synonyms:
APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1
Type:
Enzyme
Mol. Mass.:
37819.69
Organism:
Homo sapiens (Human)
Description:
gi_63102437
Residue:
339
Sequence:
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
  
Inhibitor
Name:
BDBM37863
Synonyms:
N-(5-keto-2-tosyl-3-pyrazolin-3-yl)thiophene-2-carboxamide | N-[2-(4-methylphenyl)sulfonyl-5-oxidanylidene-1H-pyrazol-3-yl]thiophene-2-carboxamide | N-[2-(4-methylphenyl)sulfonyl-5-oxo-1H-pyrazol-3-yl]-2-thiophenecarboxamide | N-[2-(4-methylphenyl)sulfonyl-5-oxo-1H-pyrazol-3-yl]thiophene-2-carboxamide | PC-0095740 | PCMD-CC-MCM-26 | cid_11834391
Type:
Small organic molecule
Emp. Form.:
C15H13N3O4S2
Mol. Mass.:
363.411
SMILES:
Cc1ccc(cc1)S(=O)(=O)n1[nH]c(=O)cc1NC(=O)c1cccs1
Structure:
Search PDB for entries with ligand similarity: