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Target
cAMP-dependent protein kinase catalytic subunit alpha
Ligand
BDBM37905
Substrate
n/a
Meas. Tech.
Dose-response biochemical assay for inhibitors of protein kinase A (PKA) activity
IC50
54810±n/a nM
Citation
 PubChem, PC Dose-response biochemical assay for inhibitors of protein kinase A (PKA) activity PubChem Bioassay (2007)[AID] 
Target
Name:
cAMP-dependent protein kinase catalytic subunit alpha
Synonyms:
KAPCA_HUMAN | PKA C-alpha | PKACA | PRKACA | cAMP-dependent protein kinase (PKA) | cAMP-dependent protein kinase catalytic (PKA) | cAMP-dependent protein kinase catalytic subunit alpha | cAMP-dependent protein kinase catalytic subunit alpha (PKA) | cAMP-dependent protein kinase catalytic subunit alpha (PKACA) | cAMP-dependent protein kinase catalytic subunit alpha (PKAc) | cAMP-dependent protein kinase catalytic subunit alpha isoform 1 | cAMP-dependent protein kinase, alpha-catalytic subunit
Type:
Enzyme Catalytic Subunit
Mol. Mass.:
40598.73
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
351
Sequence:
MGNAAAAKKGSEQESVKEFLAKAKEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF
  
Inhibitor
Name:
BDBM37905
Synonyms:
9-methyl-7-(2-pyridinyl)-5,6-dihydropyrazolo[3,4-h]quinazolin-2-amine | 9-methyl-7-pyridin-2-yl-5,6-dihydropyrazolo[3,4-h]quinazolin-2-amine | 9-methyl-7-pyridin-2-yl-6,7-dihydro-5H-pyrazolo[3,4-h]quinazolin-2-amine | MLS000085954 | SMR000021283 | [9-methyl-7-(2-pyridyl)-5,6-dihydropyrazolo[3,4-h]quinazolin-2-yl]amine | cid_712803
Type:
Small organic molecule
Emp. Form.:
C15H14N6
Mol. Mass.:
278.3119
SMILES:
Cc1nn(c2CCc3cnc(N)nc3-c12)-c1ccccn1
Structure:
Search PDB for entries with ligand similarity: