Reaction Details Report a problem with these data
Target
Diphosphomevalonate decarboxylase
Ligand
BDBM37969
Substrate
n/a
Meas. Tech.
Screening for Inhibitors of the Mevalonate Pathway in Streptococcus Pneumoniae - DPM-DC Dose Response
IC50
17591.2±n/a nM
Citation
 PubChem, PC Screening for Inhibitors of the Mevalonate Pathway in Streptococcus Pneumoniae - DPM-DC Dose Response PubChem Bioassay (2007)[AID] 
Target
Name:
Diphosphomevalonate decarboxylase
Synonyms:
n/a
Type:
Enzyme Catalytic Domain
Mol. Mass.:
35571.44
Organism:
Streptococcus pneumoniae D39
Description:
A0A0H2ZN59
Residue:
317
Sequence:
MDREPVTVRSYANIAIIKYWGKKKEKEMVPATSSISLTLENMYTETTLSPLPANVTADEFYINGQLQNEVEHAKMSKIIDRYRPAGEGFVRIDTQNNMPTAAGLSSSSSGLSALVKACNAYFKLGLDRSQLAQEAKFASGSSSRSFYGPLGAWDKDSGEIYPVETDLKLAMIMLVLEDKKKPISSRDGMKLCVETSTTFDDWVRQSEKDYQDMLIYLKENDFAKIGELTEKNALAMHATTKTASPAFSYLTDASYEAMDFVRQLREKGEACYFTMDAGPNVKVFCQEKDLEHLSEIFGQRYRLIVSKTKDLSQDDCC
  
Inhibitor
Name:
BDBM37969
Synonyms:
3-(4-Fluoro-phenyl)-1-(3-morpholin-4-yl-propyl)-1-(6-oxo-5,6-dihydro-[1,3]dioxolo[4,5-g]quinolin-7-ylmethyl)-urea | 3-(4-fluorophenyl)-1-(3-morpholin-4-ylpropyl)-1-[(6-oxidanylidene-5H-[1,3]dioxolo[4,5-g]quinolin-7-yl)methyl]urea | 3-(4-fluorophenyl)-1-(3-morpholin-4-ylpropyl)-1-[(6-oxo-5H-[1,3]dioxolo[4,5-g]quinolin-7-yl)methyl]urea | 3-(4-fluorophenyl)-1-[(6-keto-5H-[1,3]dioxolo[4,5-g]quinolin-7-yl)methyl]-1-(3-morpholinopropyl)urea | 3-(4-fluorophenyl)-1-[3-(4-morpholinyl)propyl]-1-[(6-oxo-5H-[1,3]dioxolo[4,5-g]quinolin-7-yl)methyl]urea | MLS000034288 | SMR000004162 | cid_648044
Type:
Small organic molecule
Emp. Form.:
C25H27FN4O5
Mol. Mass.:
482.5041
SMILES:
Fc1ccc(NC(=O)N(CCCN2CCOCC2)Cc2cc3cc4OCOc4cc3[nH]c2=O)cc1
Structure:
Search PDB for entries with ligand similarity: