Reaction Details Report a problem with these data
Target
Diphosphomevalonate decarboxylase
Ligand
BDBM38317
Substrate
n/a
Meas. Tech.
Screening for Inhibitors of the Mevalonate Pathway in Streptococcus Pneumoniae - DPM-DC Dose Response
IC50
27241±n/a nM
Citation
 PubChem, PC Screening for Inhibitors of the Mevalonate Pathway in Streptococcus Pneumoniae - DPM-DC Dose Response PubChem Bioassay (2007)[AID] 
Target
Name:
Diphosphomevalonate decarboxylase
Synonyms:
n/a
Type:
Enzyme Catalytic Domain
Mol. Mass.:
35571.44
Organism:
Streptococcus pneumoniae D39
Description:
A0A0H2ZN59
Residue:
317
Sequence:
MDREPVTVRSYANIAIIKYWGKKKEKEMVPATSSISLTLENMYTETTLSPLPANVTADEFYINGQLQNEVEHAKMSKIIDRYRPAGEGFVRIDTQNNMPTAAGLSSSSSGLSALVKACNAYFKLGLDRSQLAQEAKFASGSSSRSFYGPLGAWDKDSGEIYPVETDLKLAMIMLVLEDKKKPISSRDGMKLCVETSTTFDDWVRQSEKDYQDMLIYLKENDFAKIGELTEKNALAMHATTKTASPAFSYLTDASYEAMDFVRQLREKGEACYFTMDAGPNVKVFCQEKDLEHLSEIFGQRYRLIVSKTKDLSQDDCC
  
Inhibitor
Name:
BDBM38317
Synonyms:
2-imino-10-methyl-5-oxo-1-(2-phenylethyl)-3-dipyrido[3,4-c:1',2'-f]pyrimidinecarboxylic acid ethyl ester | 2-imino-5-keto-10-methyl-1-phenethyl-dipyrido[3,4-c:1',2'-f]pyrimidine-3-carboxylic acid ethyl ester | MLS000027699 | SMR000034666 | cid_660156 | ethyl 2-azanylidene-10-methyl-5-oxidanylidene-1-(2-phenylethyl)dipyrido[3,4-c:1',2'-f]pyrimidine-3-carboxylate | ethyl 2-imino-10-methyl-5-oxo-1-(2-phenylethyl)dipyrido[3,4-c:1',2'-f]pyrimidine-3-carboxylate
Type:
Small organic molecule
Emp. Form.:
C23H22N4O3
Mol. Mass.:
402.4458
SMILES:
CCOC(=O)c1cc2c(nc3c(C)cccn3c2=O)n(CCc2ccccc2)c1=N
Structure:
Search PDB for entries with ligand similarity: