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Target
Dual specificity protein phosphatase 6
Ligand
BDBM35412
Substrate
n/a
Meas. Tech.
In vitro MKP-3 Phosphatase Dose Response Hit/Probe Assessment Assay
IC50
>50000±n/a nM
Citation
 PubChem, PC In vitro MKP-3 Phosphatase Dose Response Hit/Probe Assessment Assay PubChem Bioassay (2007)[AID] 
Target
Name:
Dual specificity protein phosphatase 6
Synonyms:
DUS6_RAT | Dusp6 | MAP kinase phosphatase 3 | MKP-3 | Mitogen-activated protein kinase phosphatase 3 | Mkp3
Type:
Enzyme
Mol. Mass.:
42303.19
Organism:
Rattus norvegicus
Description:
gi_16758752
Residue:
381
Sequence:
MIDTLRPVPFASEMAISKTVAWLNEQLELGNEQLLLMDCRPQELYESSHIESAINVAIPGIMLRRLQKGNLPVRALFTRCEDRDRFTRRCGTDTVVLYDENSSDWNENTGGESVLGLLLKKLKDEGCRAFYLEGGFSKFQAEFALHCETNLDGSCSSSSPPLPVLGLGGLRISSDSSSDIESDLDRDPNSATDSDGSPLSNSQPSFPVEILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFENAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTLGLSSPCDNRVPAQQLYFTAPSNQNVYQVDSLQST
  
Inhibitor
Name:
BDBM35412
Synonyms:
MLS000092640 | N-[2-(1-cyclohexenyl)ethyl]-3-[(1,3-dimethyl-2,4-dioxo-6-quinazolinyl)sulfonylamino]propanamide | N-[2-(cyclohexen-1-yl)ethyl]-3-[(1,3-dimethyl-2,4-dioxoquinazolin-6-yl)sulfonylamino]propanamide | N-[2-(cyclohexen-1-yl)ethyl]-3-[(2,4-diketo-1,3-dimethyl-quinazolin-6-yl)sulfonylamino]propionamide | N-[2-(cyclohexen-1-yl)ethyl]-3-[[1,3-dimethyl-2,4-bis(oxidanylidene)quinazolin-6-yl]sulfonylamino]propanamide | N~1~-(2-cyclohex-1-en-1-ylethyl)-N~3~-[(1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-6-yl)sulfonyl]-beta-alaninamide | SMR000028331 | cid_3244900
Type:
Small organic molecule
Emp. Form.:
C21H28N4O5S
Mol. Mass.:
448.536
SMILES:
Cn1c2ccc(cc2c(=O)n(C)c1=O)S(=O)(=O)NCCC(=O)NCCC1=CCCCC1 |t:27|
Structure:
Search PDB for entries with ligand similarity: