Reaction Details Report a problem with these data
Target
Isoform 2 of Nuclear receptor ROR-alpha (Alpha-2)
Ligand
BDBM36897
Substrate
n/a
Meas. Tech.
Counterscreen for inhibitors of the nuclear receptor Steroidogenic Factor 1 (SF-1): A cell-based dose-response assay for inhibition of the RAR-related orphan receptor A (RORA)
IC50
1225±n/a nM
Citation
 PubChem, PC Counterscreen for inhibitors of the nuclear receptor Steroidogenic Factor 1 (SF-1): A cell-based dose-response assay for inhibition of the RAR-related orphan receptor A (RORA) PubChem Bioassay (2007)[AID] 
Target
Name:
Isoform 2 of Nuclear receptor ROR-alpha (Alpha-2)
Synonyms:
NR1F1 | Nuclear receptor ROR-alpha | Nuclear receptor ROR-alpha (Alpha-2) | Nuclear receptor ROR-alpha (Retinoid-related orphan receptor-alpha) (Nuclear receptor RZR-alpha). | RORA | RORA_HUMAN | RZRA
Type:
PROTEIN
Mol. Mass.:
63033.59
Organism:
Homo sapiens (Human)
Description:
EBI_101591
Residue:
556
Sequence:
MNEGAPGDSDLETEARVPWSIMGHCLRTGQARMSATPTPAGEGARRDELFGILQILHQCILSSGDAFVLTGVCCSWRQNGKPPYSQKEDKEVQTGYMNAQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNATYSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQQQQRDHQQQPGEAEPLTPTYNISANGLTELHDDLSNYIDGHTPEGSKADSAVSSFYLDIQPSPDQSGLDINGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLETCQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKSLGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLALQHVLQKNHREDGILTKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTSEFEPAMQIDG
  
Inhibitor
Name:
BDBM36897
Synonyms:
8-fluoranyl-4-(4-phenylpiperazin-1-yl)-5H-pyrimido[5,4-b]indole | 8-fluoro-4-(4-phenyl-1-piperazinyl)-5H-pyrimido[5,4-b]indole | 8-fluoro-4-(4-phenylpiperazin-1-yl)-5H-pyrimido[5,4-b]indole | 8-fluoro-4-(4-phenylpiperazino)-5H-pyrimid[5,4-b]indole | MLS000078400 | SMR000040426 | cid_659453
Type:
Small organic molecule
Emp. Form.:
C20H18FN5
Mol. Mass.:
347.3888
SMILES:
Fc1ccc2[nH]c3c(ncnc3c2c1)N1CCN(CC1)c1ccccc1
Structure:
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