Target
Bcl-2-related protein A1
Ligand
BDBM39167
Substrate
n/a
Meas. Tech.
TR-FRET secondary assay for HTS discovery of chemical inhibitors of anti-apoptotic protein Bfl-1
IC50
10800±910 nM
Citation
 PubChem, PC TR-FRET secondary assay for HTS discovery of chemical inhibitors of anti-apoptotic protein Bfl-1 PubChem Bioassay (2008)[AID] 
Target
Name:
Bcl-2-related protein A1
Synonyms:
A1 | A1-A | B-cell leukemia/lymphoma 2 related protein A1a | B2LA1_MOUSE | Bcl2a1 | Bcl2a1a | Bfl-1 | Bfl1 | Hemopoietic-specific early response protein | Protein BFL-1
Type:
Apoptosis regulator protein
Mol. Mass.:
19909.74
Organism:
Mus musculus (Mouse)
Description:
gi_11024684
Residue:
172
Sequence:
MAESELMHIHSLAEHYLQYVLQVPAFESAPSQACRVLQRVAFSVQKEVEKNLKSYLDDFHVESIDTARIIFNQVMEKEFEDGIINWGRIVTIFAFGGVLLKKLPQEQIALDVCAYKQVSSFVAEFIMNNTGEWIRQNGGWEDGFIKKFEPKSGWLTFLQMTGQIWEMLFLLK
  
Inhibitor
Name:
BDBM39167
Synonyms:
3-chloranyl-1-(3-methylphenyl)-4-(4-methylpiperazin-1-yl)pyrrole-2,5-dione | 3-chloro-1-(3-methylphenyl)-4-(4-Methylpiperazin-1-yl)-1H-pyrrole-2,5-dione | 3-chloro-1-(3-methylphenyl)-4-(4-methyl-1-piperazinyl)pyrrole-2,5-dione | 3-chloro-1-(3-methylphenyl)-4-(4-methylpiperazin-1-yl)pyrrole-2,5-dione | 3-chloro-4-(4-methylpiperazino)-1-(m-tolyl)-3-pyrroline-2,5-quinone | CHEMBL1271882 | MLS-0111700.0001 | cid_16654730
Type:
Small organic molecule
Emp. Form.:
C16H18ClN3O2
Mol. Mass.:
319.786
SMILES:
CN1CCN(CC1)C1=C(Cl)C(=O)N(C1=O)c1cccc(C)c1 |c:8|
Structure:
Search PDB for entries with ligand similarity: