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Target
Bcl-2-related protein A1
Ligand
BDBM39174
Substrate
n/a
Meas. Tech.
TR-FRET secondary assay for HTS discovery of chemical inhibitors of anti-apoptotic protein Bfl-1
IC50
3510±380 nM
Citation
 PubChem, PC TR-FRET secondary assay for HTS discovery of chemical inhibitors of anti-apoptotic protein Bfl-1 PubChem Bioassay (2008)[AID] 
Target
Name:
Bcl-2-related protein A1
Synonyms:
A1 | A1-A | B-cell leukemia/lymphoma 2 related protein A1a | B2LA1_MOUSE | Bcl2a1 | Bcl2a1a | Bfl-1 | Bfl1 | Hemopoietic-specific early response protein | Protein BFL-1
Type:
Apoptosis regulator protein
Mol. Mass.:
19909.74
Organism:
Mus musculus (Mouse)
Description:
gi_11024684
Residue:
172
Sequence:
MAESELMHIHSLAEHYLQYVLQVPAFESAPSQACRVLQRVAFSVQKEVEKNLKSYLDDFHVESIDTARIIFNQVMEKEFEDGIINWGRIVTIFAFGGVLLKKLPQEQIALDVCAYKQVSSFVAEFIMNNTGEWIRQNGGWEDGFIKKFEPKSGWLTFLQMTGQIWEMLFLLK
  
Inhibitor
Name:
BDBM39174
Synonyms:
3-chloranyl-4-[4-[2-(2-hydroxyethyloxy)ethyl]piperazin-1-yl]-1-(4-nitrophenyl)pyrrole-2,5-dione | 3-chloro-4-[4-[2-(2-hydroxyethoxy)ethyl]-1-piperazinyl]-1-(4-nitrophenyl)pyrrole-2,5-dione | 3-chloro-4-[4-[2-(2-hydroxyethoxy)ethyl]piperazin-1-yl]-1-(4-nitrophenyl)pyrrole-2,5-dione | 3-chloro-4-[4-[2-(2-hydroxyethoxy)ethyl]piperazino]-1-(4-nitrophenyl)-3-pyrroline-2,5-quinone | MLS-0111731.0001 | cid_16654760
Type:
Small organic molecule
Emp. Form.:
C18H21ClN4O6
Mol. Mass.:
424.836
SMILES:
OCCOCCN1CCN(CC1)C1=C(Cl)C(=O)N(C1=O)c1ccc(cc1)[N+]([O-])=O |c:13|
Structure:
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