Reaction Details Report a problem with these data
Target
Isoform 2 of Nuclear receptor ROR-alpha (Alpha-2)
Ligand
BDBM39423
Substrate
n/a
Meas. Tech.
Counterscreen for activators of the nuclear receptor Steroidogenic Factor 1 (SF-1): A cell-based dose-response assay for inhibition of the RAR-related orphan receptor A (RORA)
EC50
2714±n/a nM
Citation
 PubChem, PC Counterscreen for activators of the nuclear receptor Steroidogenic Factor 1 (SF-1): A cell-based dose-response assay for inhibition of the RAR-related orphan receptor A (RORA) PubChem Bioassay (2007)[AID] 
Target
Name:
Isoform 2 of Nuclear receptor ROR-alpha (Alpha-2)
Synonyms:
NR1F1 | Nuclear receptor ROR-alpha | Nuclear receptor ROR-alpha (Alpha-2) | Nuclear receptor ROR-alpha (Retinoid-related orphan receptor-alpha) (Nuclear receptor RZR-alpha). | RORA | RORA_HUMAN | RZRA
Type:
PROTEIN
Mol. Mass.:
63033.59
Organism:
Homo sapiens (Human)
Description:
EBI_101591
Residue:
556
Sequence:
MNEGAPGDSDLETEARVPWSIMGHCLRTGQARMSATPTPAGEGARRDELFGILQILHQCILSSGDAFVLTGVCCSWRQNGKPPYSQKEDKEVQTGYMNAQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNATYSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQQQQRDHQQQPGEAEPLTPTYNISANGLTELHDDLSNYIDGHTPEGSKADSAVSSFYLDIQPSPDQSGLDINGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLETCQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKSLGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLALQHVLQKNHREDGILTKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTSEFEPAMQIDG
  
Inhibitor
Name:
BDBM39423
Synonyms:
Furan-2-carboxylic acid {5-[(thiophene-2-carbonyl)-amino]-pyridin-2-yl}-amide | MLS000034423 | N-[5-(2-thenoylamino)-2-pyridyl]-2-furamide | N-[5-(thiophen-2-ylcarbonylamino)pyridin-2-yl]furan-2-carboxamide | N-[5-(thiophene-2-carbonylamino)pyridin-2-yl]furan-2-carboxamide | N-[5-[[oxo(thiophen-2-yl)methyl]amino]-2-pyridinyl]-2-furancarboxamide | SMR000005507 | cid_647091
Type:
Small organic molecule
Emp. Form.:
C15H11N3O3S
Mol. Mass.:
313.331
SMILES:
O=C(Nc1ccc(NC(=O)c2cccs2)cn1)c1ccco1
Structure:
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