Reaction Details Report a problem with these data
Target
Coagulation factor XI
Ligand
BDBM32726
Substrate
n/a
Meas. Tech.
Factor XIa Dose Response Confirmation
IC50
>50000±0 nM
Citation
 PubChem, PC Factor XIa Dose Response Confirmation PubChem Bioassay (2008)[AID] 
Target
Name:
Coagulation factor XI
Synonyms:
Coagulation factor XIa | Coagulation factor XIa heavy chain | Coagulation factor XIa light chain | F11 | FA11_HUMAN | FXI | Factor XIa | Factor XIa (fXIa) | PTA | Plasma thromboplastin antecedent
Type:
Enzyme
Mol. Mass.:
70130.58
Organism:
Homo sapiens (Human)
Description:
P03951
Residue:
625
Sequence:
MIFLYQVVHFILFTSVSGECVTQLLKDTCFEGGDITTVFTPSAKYCQVVCTYHPRCLLFTFTAESPSEDPTRWFTCVLKDSVTETLPRVNRTAAISGYSFKQCSHQISACNKDIYVDLDMKGINYNSSVAKSAQECQERCTDDVHCHFFTYATRQFPSLEHRNICLLKHTQTGTPTRITKLDKVVSGFSLKSCALSNLACIRDIFPNTVFADSNIDSVMAPDAFVCGRICTHHPGCLFFTFFSQEWPKESQRNLCLLKTSESGLPSTRIKKSKALSGFSLQSCRHSIPVFCHSSFYHDTDFLGEELDIVAAKSHEACQKLCTNAVRCQFFTYTPAQASCNEGKGKCYLKLSSNGSPTKILHGRGGISGYTLRLCKMDNECTTKIKPRIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVESPKILRVYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLETTVNYTDSQRPICLPSKGDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKIPLVTNEECQKRYRGHKITHKMICAGYREGGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCAQRERPGVYTNVVEYVDWILEKTQAV
  
Inhibitor
Name:
BDBM32726
Synonyms:
(4-fluorophenyl)-(4-nicotinoylpiperazino)methanone | (4-fluorophenyl)-(4-pyridin-3-ylcarbonylpiperazin-1-yl)methanone | (4-fluorophenyl)-[4-(pyridine-3-carbonyl)piperazin-1-yl]methanone | (4-fluorophenyl)-[4-[oxo(3-pyridinyl)methyl]-1-piperazinyl]methanone | 1-(4-fluorobenzoyl)-4-(3-pyridinylcarbonyl)piperazine | MLS000533540 | SMR000140978 | cid_776712
Type:
Small organic molecule
Emp. Form.:
C17H16FN3O2
Mol. Mass.:
313.3262
SMILES:
Fc1ccc(cc1)C(=O)N1CCN(CC1)C(=O)c1cccnc1
Structure:
Search PDB for entries with ligand similarity: