Reaction Details Report a problem with these data
Target
Coagulation factor XI
Ligand
BDBM32732
Substrate
n/a
Meas. Tech.
Factor XIa Dose Response Confirmation
IC50
588.113±40.8393 nM
Citation
 PubChem, PC Factor XIa Dose Response Confirmation PubChem Bioassay (2008)[AID] 
Target
Name:
Coagulation factor XI
Synonyms:
Coagulation factor XIa | Coagulation factor XIa heavy chain | Coagulation factor XIa light chain | F11 | FA11_HUMAN | FXI | Factor XIa | Factor XIa (fXIa) | PTA | Plasma thromboplastin antecedent
Type:
Enzyme
Mol. Mass.:
70130.58
Organism:
Homo sapiens (Human)
Description:
P03951
Residue:
625
Sequence:
MIFLYQVVHFILFTSVSGECVTQLLKDTCFEGGDITTVFTPSAKYCQVVCTYHPRCLLFTFTAESPSEDPTRWFTCVLKDSVTETLPRVNRTAAISGYSFKQCSHQISACNKDIYVDLDMKGINYNSSVAKSAQECQERCTDDVHCHFFTYATRQFPSLEHRNICLLKHTQTGTPTRITKLDKVVSGFSLKSCALSNLACIRDIFPNTVFADSNIDSVMAPDAFVCGRICTHHPGCLFFTFFSQEWPKESQRNLCLLKTSESGLPSTRIKKSKALSGFSLQSCRHSIPVFCHSSFYHDTDFLGEELDIVAAKSHEACQKLCTNAVRCQFFTYTPAQASCNEGKGKCYLKLSSNGSPTKILHGRGGISGYTLRLCKMDNECTTKIKPRIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVESPKILRVYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLETTVNYTDSQRPICLPSKGDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKIPLVTNEECQKRYRGHKITHKMICAGYREGGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCAQRERPGVYTNVVEYVDWILEKTQAV
  
Inhibitor
Name:
BDBM32732
Synonyms:
MLS000554787 | N-(5-ethyl-3-bicyclo[2.2.1]heptanyl)acetamide | N-(5-ethyl-3-bicyclo[2.2.1]heptanyl)ethanamide | N-(6-Ethyl-bicyclo[2.2.1]hept-2-yl)-acetamide | N-(6-ethylnorbornan-2-yl)acetamide | SMR000146904 | cid_4896559
Type:
Small organic molecule
Emp. Form.:
C11H19NO
Mol. Mass.:
181.2747
SMILES:
[H]C12CC(CC)C([H])(C1)C(C2)NC(C)=O |TLB:11:9:8:3.2,THB:4:3:8:9.10|
Structure:
Search PDB for entries with ligand similarity: