Reaction Details Report a problem with these data
Target
Isoform 2 of Nuclear receptor ROR-alpha (Alpha-2)
Ligand
BDBM39527
Substrate
n/a
Meas. Tech.
Dose-response cell-based assay for activators of the Retinoic Acid Receptor-related orphan receptor A (RORA)
EC50
>136±n/a nM
Citation
 PubChem, PC Dose-response cell-based assay for activators of the Retinoic Acid Receptor-related orphan receptor A (RORA) PubChem Bioassay (2007)[AID] 
Target
Name:
Isoform 2 of Nuclear receptor ROR-alpha (Alpha-2)
Synonyms:
NR1F1 | Nuclear receptor ROR-alpha | Nuclear receptor ROR-alpha (Alpha-2) | Nuclear receptor ROR-alpha (Retinoid-related orphan receptor-alpha) (Nuclear receptor RZR-alpha). | RORA | RORA_HUMAN | RZRA
Type:
PROTEIN
Mol. Mass.:
63033.59
Organism:
Homo sapiens (Human)
Description:
EBI_101591
Residue:
556
Sequence:
MNEGAPGDSDLETEARVPWSIMGHCLRTGQARMSATPTPAGEGARRDELFGILQILHQCILSSGDAFVLTGVCCSWRQNGKPPYSQKEDKEVQTGYMNAQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNATYSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQQQQRDHQQQPGEAEPLTPTYNISANGLTELHDDLSNYIDGHTPEGSKADSAVSSFYLDIQPSPDQSGLDINGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLETCQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKSLGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLALQHVLQKNHREDGILTKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTSEFEPAMQIDG
  
Inhibitor
Name:
BDBM39527
Synonyms:
MLS000070707 | N-(6-ethoxy-1,3-benzothiazol-2-yl)-2-pyrazinecarboxamide | N-(6-ethoxy-1,3-benzothiazol-2-yl)pyrazinamide | N-(6-ethoxy-1,3-benzothiazol-2-yl)pyrazine-2-carboxamide | Pyrazine-2-carboxylic acid (6-ethoxy-benzothiazol-2-yl)-amide | SMR000012260 | cid_655450
Type:
Small organic molecule
Emp. Form.:
C14H12N4O2S
Mol. Mass.:
300.336
SMILES:
CCOc1ccc2nc(NC(=O)c3cnccn3)sc2c1
Structure:
Search PDB for entries with ligand similarity: