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Target
Alkaline phosphatase, germ cell type
Ligand
BDBM39775
Substrate
n/a
Meas. Tech.
Luminescent assay for HTS discovery of chemical inhibitors of placental alkaline phosphatase
IC50
9810±330 nM
Citation
 PubChem, PC Luminescent assay for HTS discovery of chemical inhibitors of placental alkaline phosphatase PubChem Bioassay (2007)[AID] 
Target
Name:
Alkaline phosphatase, germ cell type
Synonyms:
ALPG | ALPPL | ALPPL2 | Alkaline phosphatase placental-like | PPBN_HUMAN | placental-like alkaline phosphatase preproprotein
Type:
PROTEIN
Mol. Mass.:
57374.31
Organism:
Homo sapiens (Human)
Description:
ChEMBL_29964
Residue:
532
Sequence:
MQGPWVLLLLGLRLQLSLGIIPVEEENPDFWNRQAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPETFLAMDRFPYVALSKTYSVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGAYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFPMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKHQGARYVWNRTELLQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALLLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDGETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPRAGTTDAAHPGPSVVPALLPLLAGTLLLLGTATAP
  
Inhibitor
Name:
BDBM39775
Synonyms:
(5E)-5-[(E)-3-[4-(dimethylamino)phenyl]prop-2-enylidene]-3-phenyl-2-sulfanylidene-1,3-thiazolidin-4-one | (5E)-5-[(E)-3-[4-(dimethylamino)phenyl]prop-2-enylidene]-3-phenyl-2-sulfanylidene-4-thiazolidinone | (5E)-5-[(E)-3-[4-(dimethylamino)phenyl]prop-2-enylidene]-3-phenyl-2-thioxo-thiazolidin-4-one | 5-[3-(4-Dimethylamino-phenyl)-allylidene]-3-phenyl-2-thioxo-thiazolidin-4-one | MLS000557712 | SMR000174254 | cid_5752007
Type:
Small organic molecule
Emp. Form.:
C20H18N2OS2
Mol. Mass.:
366.5
SMILES:
CN(C)c1ccc(\C=C\C=C2\SC(=S)N(C2=O)c2ccccc2)cc1
Structure:
Search PDB for entries with ligand similarity: