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Target
14-3-3 protein gamma
Ligand
BDBM39873
Substrate
n/a
Meas. Tech.
14-3-3 protein interaction modulators Dose Response Confirmation
IC50
>50000±n/a nM
Citation
 PubChem, PC 14-3-3 protein interaction modulators Dose Response Confirmation PubChem Bioassay (2007)[AID] 
Target
Name:
14-3-3 protein gamma
Synonyms:
1433G_HUMAN | YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
Type:
Enzyme Catalytic Domain
Mol. Mass.:
28289.17
Organism:
Homo sapiens (Human)
Description:
gi_21464101
Residue:
247
Sequence:
MVDREQLVQKARLAEQAERYDDMAAAMKNVTELNEPLSNEERNLLSVAYKNVVGARRSSWRVISSIEQKTSADGNEKKIEMVRAYREKIEKELEAVCQDVLSLLDNYLIKNCSETQYESKVFYLKMKGDYYRYLAEVATGEKRATVVESSEKAYSEAHEISKEHMQPTHPIRLGLALNYSVFYYEIQNAPEQACHLAKTAFDDAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDQQDDDGGEGNN
  
Inhibitor
Name:
BDBM39873
Synonyms:
4-amino-N-[2-[[(E)-(3-benzyl-5-bromo-6-keto-cyclohexa-2,4-dien-1-ylidene)methyl]amino]ethyl]furazan-3-carboxamide | 4-amino-N-[2-[[(E)-(3-benzyl-5-bromo-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino]ethyl]-1,2,5-oxadiazole-3-carboxamide | 4-amino-N-[2-[[(E)-[5-bromo-6-oxo-3-(phenylmethyl)-1-cyclohexa-2,4-dienylidene]methyl]amino]ethyl]-1,2,5-oxadiazole-3-carboxamide | 4-azanyl-N-[2-[[(E)-[5-bromanyl-6-oxidanylidene-3-(phenylmethyl)cyclohexa-2,4-dien-1-ylidene]methyl]amino]ethyl]-1,2,5-oxadiazole-3-carboxamide | MLS000077667 | SMR000035956 | cid_5389398
Type:
Small organic molecule
Emp. Form.:
C19H18BrN5O3
Mol. Mass.:
444.282
SMILES:
Nc1nonc1C(=O)NCCN=Cc1cc(Cc2ccccc2)cc(Br)c1O |w:11.11|
Structure:
Search PDB for entries with ligand similarity: