Reaction Details Report a problem with these data
Target
14-3-3 protein gamma
Ligand
BDBM32120
Substrate
n/a
Meas. Tech.
14-3-3 protein interaction modulators Dose Response Confirmation
IC50
10660.4±n/a nM
Citation
 PubChem, PC 14-3-3 protein interaction modulators Dose Response Confirmation PubChem Bioassay (2007)[AID] 
Target
Name:
14-3-3 protein gamma
Synonyms:
1433G_HUMAN | YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
Type:
Enzyme Catalytic Domain
Mol. Mass.:
28289.17
Organism:
Homo sapiens (Human)
Description:
gi_21464101
Residue:
247
Sequence:
MVDREQLVQKARLAEQAERYDDMAAAMKNVTELNEPLSNEERNLLSVAYKNVVGARRSSWRVISSIEQKTSADGNEKKIEMVRAYREKIEKELEAVCQDVLSLLDNYLIKNCSETQYESKVFYLKMKGDYYRYLAEVATGEKRATVVESSEKAYSEAHEISKEHMQPTHPIRLGLALNYSVFYYEIQNAPEQACHLAKTAFDDAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDQQDDDGGEGNN
  
Inhibitor
Name:
BDBM32120
Synonyms:
2-[[2-(4-methoxyphenyl)-5-methyl-1,3-oxazol-4-yl]methylsulfinyl]-N-(pyridin-2-ylmethyl)acetamide | 2-[[2-(4-methoxyphenyl)-5-methyl-1,3-oxazol-4-yl]methylsulfinyl]-N-(pyridin-2-ylmethyl)ethanamide | 2-[[2-(4-methoxyphenyl)-5-methyl-4-oxazolyl]methylsulfinyl]-N-(2-pyridinylmethyl)acetamide | 2-[[2-(4-methoxyphenyl)-5-methyl-oxazol-4-yl]methylsulfinyl]-N-(2-pyridylmethyl)acetamide | MLS000117623 | SMR000094571 | cid_5308158
Type:
Small organic molecule
Emp. Form.:
C20H21N3O4S
Mol. Mass.:
399.463
SMILES:
COc1ccc(cc1)-c1nc(CS(=O)CC(=O)NCc2ccccn2)c(C)o1
Structure:
Search PDB for entries with ligand similarity: