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Target
Ubiquitin carboxyl-terminal hydrolase BAP1
Ligand
BDBM40277
Substrate
n/a
Meas. Tech.
BAP1 Enzyme inhibitors Dose Response Confirmation
IC50
>50000±n/a nM
Citation
 PubChem, PC BAP1 Enzyme inhibitors Dose Response Confirmation PubChem Bioassay (2007)[AID] 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase BAP1
Synonyms:
BAP1 | BAP1_HUMAN | KIAA0272 | Ubiquitin carboxyl-terminal hydrolase BAP1 (BRCA1-associated protein 1) (Cerebral protein 6).
Type:
Enzyme Catalytic Domain
Mol. Mass.:
80364.15
Organism:
Homo sapiens (Human)
Description:
gi_68565074
Residue:
729
Sequence:
MNKGWLELESDPGLFTLLVEDFGVKGVQVEEIYDLQSKCQGPVYGFIFLFKWIEERRSRRKVSTLVDDTSVIDDDIVNNMFFAHQLIPNSCATHALLSVLLNCSSVDLGPTLSRMKDFTKGFSPESKGYAIGNAPELAKAHNSHARPEPRHLPEKQNGLSAVRTMEAFHFVSYVPITGRLFELDGLKVYPIDHGPWGEDEEWTDKARRVIMERIGLATAGEPYHDIRFNLMAVVPDRRIKYEARLHVLKVNRQTVLEALQQLIRVTQPELIQTHKSQESQLPEESKSASNKSPLVLEANRAPAASEGNHTDGAEEAAGSCAQAPSHSPPNKPKLVVKPPGSSLNGVHPNPTPIVQRLPAFLDNHNYAKSPMQEEEDLAAGVGRSRVPVRPPQQYSDDEDDYEDDEEDDVQNTNSALRYKGKGTGKPGALSGSADGQLSVLQPNTINVLAEKLKESQKDLSIPLSIKTSSGAGSPAVAVPTHSQPSPTPSNESTDTASEIGSAFNSPLRSPIRSANPTRPSSPVTSHISKVLFGEDDSLLRVDCIRYNRAVRDLGPVISTGLLHLAEDGVLSPLALTEGGKGSSPSIRPIQGSQGSSSPVEKEVVEATDSREKTGMVRPGEPLSGEKYSPKELLALLKCVEAEIANYEACLKEEVEKRKKFKIDDQRRTHNYDEFICTFISMLAQEGMLANLVEQNISVRRRQGVSIGRLHKQRKPDRRKRSRPYKAKRQ
  
Inhibitor
Name:
BDBM40277
Synonyms:
1-(4-Chloro-benzenesulfonyl)-piperidine-4-carboxylic acid (5-furan-2-yl-[1,3,4]thiadiazol-2-yl)-amide | 1-(4-chlorophenyl)sulfonyl-N-[5-(2-furanyl)-1,3,4-thiadiazol-2-yl]-4-piperidinecarboxamide | 1-(4-chlorophenyl)sulfonyl-N-[5-(2-furyl)-1,3,4-thiadiazol-2-yl]isonipecotamide | 1-(4-chlorophenyl)sulfonyl-N-[5-(furan-2-yl)-1,3,4-thiadiazol-2-yl]piperidine-4-carboxamide | MLS000034703 | SMR000003875 | cid_651894
Type:
Small organic molecule
Emp. Form.:
C18H17ClN4O4S2
Mol. Mass.:
452.935
SMILES:
Clc1ccc(cc1)S(=O)(=O)N1CCC(CC1)C(=O)Nc1nnc(s1)-c1ccco1
Structure:
Search PDB for entries with ligand similarity: