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Target
Ubiquitin carboxyl-terminal hydrolase BAP1
Ligand
BDBM40286
Substrate
n/a
Meas. Tech.
BAP1 Enzyme inhibitors Dose Response Confirmation
IC50
>50000±n/a nM
Citation
 PubChem, PC BAP1 Enzyme inhibitors Dose Response Confirmation PubChem Bioassay (2007)[AID] 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase BAP1
Synonyms:
BAP1 | BAP1_HUMAN | KIAA0272 | Ubiquitin carboxyl-terminal hydrolase BAP1 (BRCA1-associated protein 1) (Cerebral protein 6).
Type:
Enzyme Catalytic Domain
Mol. Mass.:
80364.15
Organism:
Homo sapiens (Human)
Description:
gi_68565074
Residue:
729
Sequence:
MNKGWLELESDPGLFTLLVEDFGVKGVQVEEIYDLQSKCQGPVYGFIFLFKWIEERRSRRKVSTLVDDTSVIDDDIVNNMFFAHQLIPNSCATHALLSVLLNCSSVDLGPTLSRMKDFTKGFSPESKGYAIGNAPELAKAHNSHARPEPRHLPEKQNGLSAVRTMEAFHFVSYVPITGRLFELDGLKVYPIDHGPWGEDEEWTDKARRVIMERIGLATAGEPYHDIRFNLMAVVPDRRIKYEARLHVLKVNRQTVLEALQQLIRVTQPELIQTHKSQESQLPEESKSASNKSPLVLEANRAPAASEGNHTDGAEEAAGSCAQAPSHSPPNKPKLVVKPPGSSLNGVHPNPTPIVQRLPAFLDNHNYAKSPMQEEEDLAAGVGRSRVPVRPPQQYSDDEDDYEDDEEDDVQNTNSALRYKGKGTGKPGALSGSADGQLSVLQPNTINVLAEKLKESQKDLSIPLSIKTSSGAGSPAVAVPTHSQPSPTPSNESTDTASEIGSAFNSPLRSPIRSANPTRPSSPVTSHISKVLFGEDDSLLRVDCIRYNRAVRDLGPVISTGLLHLAEDGVLSPLALTEGGKGSSPSIRPIQGSQGSSSPVEKEVVEATDSREKTGMVRPGEPLSGEKYSPKELLALLKCVEAEIANYEACLKEEVEKRKKFKIDDQRRTHNYDEFICTFISMLAQEGMLANLVEQNISVRRRQGVSIGRLHKQRKPDRRKRSRPYKAKRQ
  
Inhibitor
Name:
BDBM40286
Synonyms:
6-(2,3-dihydro-1,4-benzodioxin-6-ylsulfamoyl)-4-oxidanylidene-N-(phenylmethyl)-1H-quinoline-3-carboxamide | 6-(2,3-dihydro-1,4-benzodioxin-6-ylsulfamoyl)-4-oxo-N-(phenylmethyl)-1H-quinoline-3-carboxamide | MLS000046788 | N-benzyl-6-(2,3-dihydro-1,4-benzodioxin-6-ylsulfamoyl)-4-keto-1H-quinoline-3-carboxamide | N-benzyl-6-(2,3-dihydro-1,4-benzodioxin-6-ylsulfamoyl)-4-oxo-1H-quinoline-3-carboxamide | N-benzyl-6-[(2,3-dihydro-1,4-benzodioxin-6-ylamino)sulfonyl]-4-oxo-1,4-dihydroquinoline-3-carboxamide | SMR000032799 | cid_3235681
Type:
Small organic molecule
Emp. Form.:
C25H21N3O6S
Mol. Mass.:
491.516
SMILES:
Oc1c(cnc2ccc(cc12)S(=O)(=O)Nc1ccc2OCCOc2c1)C(=O)NCc1ccccc1
Structure:
Search PDB for entries with ligand similarity: